Cited 5 times in
Association between polymorphism of tumor necrosis factor-alpha promoter and response to lamivudine treatment in patients with chronic hepatitis B.
DC Field | Value | Language |
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dc.contributor.author | 박용광 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 이관식 | - |
dc.contributor.author | 이중민 | - |
dc.contributor.author | 장혜영 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | 김도영 | - |
dc.contributor.author | 김자경 | - |
dc.date.accessioned | 2015-04-23T17:06:57Z | - |
dc.date.available | 2015-04-23T17:06:57Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101849 | - |
dc.description.abstract | BACKGROUND: TNF-alpha promoter polymorphism is known to play an important role in the immunopathogenesis of infection of hepatitis B virus. AIMS: We investigated whether polymorphisms of TNF-alpha promoter at position -308 or -238 had associations with the response to lamivudine treatment. METHODS: A total of 89 healthy subjects (control group) and 225 patients with chronic hepatitis B treated with lamivudine were included in this study. Polymorphisms of TNF-alpha promoter at position -308 and -238 were analyzed by polymerase chain reaction. Recruited patients were classified according to the outcome of lamivudine treatment into the responder (103 patients) or non-responder (122 patients) group. RESULTS: The numbers of A allelic polymorphism of TNF-alpha promoter at position -238 were four (2.2%) in the control, five (2.4%) in the responder and 19 (7.8%) in the non-responder group. The A allele was noted significantly more frequently in the responder than non-responder group (P = 0.012). At position -308, a significant difference was observed between the control group (14; 7.9%) and total chronic hepatitis B patients (15; 3.3%) (P = 0.015). CONCLUSIONS: Our study demonstrated that the non-response to lamivudine treatment in patients with chronic hepatitis B might be related to the A allelic polymorphism of TNF-alpha promoter at position -238. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | DIGESTIVE DISEASES AND SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Confidence Intervals | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Hepatitis B, Chronic/diagnosis | - |
dc.subject.MESH | Hepatitis B, Chronic/drug therapy* | - |
dc.subject.MESH | Hepatitis B, Chronic/genetics* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lamivudine/therapeutic use* | - |
dc.subject.MESH | Liver Function Tests | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Probability | - |
dc.subject.MESH | Promoter Regions, Genetic/drug effects* | - |
dc.subject.MESH | Reference Values | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Treatment Failure | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/genetics* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/metabolism | - |
dc.subject.MESH | Young Adult | - |
dc.title | Association between polymorphism of tumor necrosis factor-alpha promoter and response to lamivudine treatment in patients with chronic hepatitis B. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yong Kwang Park | - |
dc.contributor.googleauthor | Jung Min Lee | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Hye Young Chang | - |
dc.contributor.googleauthor | Ja Kyung Kim | - |
dc.contributor.googleauthor | Chun Kyon Lee | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Kwan Sik Lee | - |
dc.contributor.googleauthor | Kwang Hyub Han | - |
dc.identifier.doi | 10.1007/s10620-009-0983-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01577 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02666 | - |
dc.contributor.localId | A03252 | - |
dc.contributor.localId | A03495 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A00852 | - |
dc.contributor.localId | A03184 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J00737 | - |
dc.identifier.eissn | 1573-2568 | - |
dc.identifier.pmid | 19830555 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10620-009-0983-1 | - |
dc.subject.keyword | Hepatitis B virus | - |
dc.subject.keyword | Lamivudine | - |
dc.subject.keyword | Tumor necrosis factor-alpha | - |
dc.subject.keyword | Single nucleotide polymorphism | - |
dc.contributor.alternativeName | Park, Yong Kwang | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Lee, Kwan Sik | - |
dc.contributor.alternativeName | Lee, Jung Min | - |
dc.contributor.alternativeName | Lee, Chun Kyon | - |
dc.contributor.alternativeName | Chang, Hye Young | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Kim, Ja Kyung | - |
dc.contributor.affiliatedAuthor | Park, Yong Kwang | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Kwan Sik | - |
dc.contributor.affiliatedAuthor | Lee, Chun Kyon | - |
dc.contributor.affiliatedAuthor | Chang, Hye Young | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Ja Kyung | - |
dc.contributor.affiliatedAuthor | Lee, Jung Min | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.citation.volume | 55 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2043 | - |
dc.citation.endPage | 2048 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, Vol.55(7) : 2043-2048, 2010 | - |
dc.identifier.rimsid | 54651 | - |
dc.type.rims | ART | - |
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