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Increase of ceftazidime- and fluoroquinolone-resistant Klebsiella pneumoniae and imipenem-resistant Acinetobacter spp. in Korea: analysis of KONSAR study data from 2005 and 2007

Authors
 Kyungwon Lee  ;  Mi Ae Lee  ;  Chae Hoon Lee  ;  Jongwook Lee  ;  Kyoung Ho Roh  ;  Sunjoo Kim  ;  Jin Ju Kim  ;  Eunmi Koh  ;  Dongeun Yong  ;  Yunsop Chong 
Citation
 YONSEI MEDICAL JOURNAL, Vol.51(6) : 901-911, 2010 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2010
MeSH
Acinetobacter/metabolism* ; Bacterial Infections/drug therapy ; Bacterial Infections/epidemiology* ; Ceftazidime/pharmacology* ; Cross Infection/drug therapy ; Cross Infection/epidemiology* ; Drug Resistance, Bacterial* ; Escherichia coli/metabolism ; Fluoroquinolones/pharmacology* ; Humans ; Imipenem/pharmacology* ; Klebsiella Infections/drug therapy* ; Klebsiella pneumoniae/metabolism* ; Methicillin-Resistant Staphylococcus aureus/metabolism ; Pseudomonas aeruginosa/metabolism ; Republic of Korea ; Vancomycin/pharmacology
Keywords
Antimicrobial resistance surveillance ; Korea ; vancomycin resistance ; fluoroquinolone resistance ; imipenem resistance ; MRSA ; P. aeruginosa ; Acinetobacter spp
Abstract
PURPOSE: Antimicrobial resistance monitoring could be a useful source of information for treating and controlling nosocomial infections. We analyzed antimicrobial resistance data generated by Korean Hospitals and by a commercial laboratory in 2005 and 2007.

MATERIALS AND METHODS: Susceptibility data for 2005 and 2007 were collected from 37 and 41 hospitals, respectively, and from one commercial laboratory. Intermediate susceptibility was not included in the calculation of resistance rates.

RESULTS: Methicillin-resistant Staphylococcus aureus (MRSA) (64%), third-generation cephalosporin-resistant Klebsiella pneumoniae (29%), fluoroquinolone-resistant Escherichia coli (27%), Pseudomonas aeruginosa (33%), and Acinetobacter spp. (48%), and amikacin-resistant P. aeruginosa (19%) and Acinetobacter spp. (37%) were prevalent in hospitals in 2007. A gradual increase of vancomycin-resistant Enterococcus faecium and imipenem-resistant Acinetobacter spp. was observed. Higher incidences of thirdgeneration cephalosporin-resistant E. coli and K. pneumoniae and imipenemresistant P. aeruginosa were found in the commercial laboratory than in the hospitals.

CONCLUSION: Methicillin-resistant S. aureus, third-generation cephalosporin- resistant K. pneumoniae, and fluoroquinolone-resistant E. coli, P. aeruginosa and Acinetobacter spp. remain prevalent in Korea, while the incidence of vancomycin-resistant E. faecium and imipenem-resistant Acinetobacter spp. has increased gradually. The higher prevalences of third-generation cephalosporinresistant E. coli and K. pneumoniae, and imipenem-resistant P. aeruginosa in the commercial laboratory are a new concern.
Files in This Item:
T201002828.pdf Download
DOI
10.3349/ymj.2010.51.6.901
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Eun Mi(고은미)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Chong, Yun Sop(정윤섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101772
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