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HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells

DC FieldValueLanguage
dc.contributor.author강희범-
dc.contributor.author김미정-
dc.contributor.author김한천-
dc.contributor.author윤호근-
dc.contributor.author이옥희-
dc.contributor.author최경철-
dc.contributor.author최효경-
dc.date.accessioned2015-04-23T17:04:11Z-
dc.date.available2015-04-23T17:04:11Z-
dc.date.issued2010-
dc.identifier.issn1420-682X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101764-
dc.description.abstractWe identified CREB3 as a novel HDAC3-interacting protein in a yeast two-hybrid screen for HDAC3-interacting proteins. Among all class I HDACs, CREB3 specifically interacts with HDAC3, in vitro and in vivo. HDAC3 efficiently inhibited CREB3-enhanced NF-κB activation, whereas the other class I HDACs did not alter NF-κB-dependent promoter activities or the expression of NF-κB target genes. Importantly, both knock-down of CREB3 and overexpression of HDAC3 suppressed the transcriptional activation of the novel CREB3-regulated gene, CXCR4. Furthermore, CREB3 was shown to bind to the CRE element in the CXCR4 promoter and to activate the transcription of the CXCR4 gene by causing dissociation of HDAC3 and subsequently increasing histone acetylation. Importantly, both the depletion of HDAC3 and the overexpression of CREB3 substantially increased the migration of MDA-MB-231 metastatic breast cancer cells. Taken together, these findings suggest that HDAC3 selectively represses CREB3-mediated transcriptional activation and chemotactic signalling in human metastatic breast cancer cells.-
dc.description.statementOfResponsibilityopen-
dc.format.extent3499~3510-
dc.relation.isPartOfCELLULAR AND MOLECULAR LIFE SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBreast Neoplasms/enzymology*-
dc.subject.MESHBreast Neoplasms/genetics-
dc.subject.MESHBreast Neoplasms/pathology*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Movement*-
dc.subject.MESHCyclic AMP Response Element-Binding Protein/chemistry-
dc.subject.MESHCyclic AMP Response Element-Binding Protein/metabolism*-
dc.subject.MESHDown-Regulation/genetics-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHistone Deacetylases/chemistry-
dc.subject.MESHHistone Deacetylases/metabolism*-
dc.subject.MESHHumans-
dc.subject.MESHNF-kappa B/metabolism-
dc.subject.MESHNeoplasm Metastasis/genetics-
dc.subject.MESHNeoplasm Metastasis/pathology-
dc.subject.MESHProtein Binding-
dc.subject.MESHProtein Interaction Mapping-
dc.subject.MESHProtein Structure, Tertiary-
dc.subject.MESHReceptors, CXCR4/genetics-
dc.subject.MESHReceptors, CXCR4/metabolism-
dc.subject.MESHRepressor Proteins/metabolism*-
dc.subject.MESHTranscription, Genetic*-
dc.titleHDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorHan-Cheon Kim-
dc.contributor.googleauthorKyung-Chul Choi-
dc.contributor.googleauthorHyo-Kyoung Choi-
dc.contributor.googleauthorHee-Bum Kang-
dc.contributor.googleauthorMi-Jeong Kim-
dc.contributor.googleauthorYoo-Hyun Lee-
dc.contributor.googleauthorOk-Hee Lee-
dc.contributor.googleauthorJeongmin Lee-
dc.contributor.googleauthorYoung Jun Kim-
dc.contributor.googleauthorWoojin Jun-
dc.contributor.googleauthorJae-Wook Jeong-
dc.contributor.googleauthorHo-Geun Yoon-
dc.identifier.doi10.1007/s00018-010-0388-5-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00103-
dc.contributor.localIdA01103-
dc.contributor.localIdA02625-
dc.contributor.localIdA02970-
dc.contributor.localIdA04035-
dc.contributor.localIdA04225-
dc.contributor.localIdA00450-
dc.relation.journalcodeJ00496-
dc.identifier.eissn1420-9071-
dc.identifier.pmid20473547-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00018-010-0388-5-
dc.subject.keywordHistone deacetylase 3-
dc.subject.keywordcAMP response element-binding protein 3 (CREB3)-
dc.subject.keywordChemokine-
dc.subject.keywordCXC motif-
dc.subject.keywordReceptor 4 (CXCR4)-
dc.subject.keywordMigration-
dc.subject.keywordBreast cancer cell-
dc.contributor.alternativeNameKang, Hee Bum-
dc.contributor.alternativeNameKim, Mi Jeong-
dc.contributor.alternativeNameKim, Han Cheon-
dc.contributor.alternativeNameYoon, Ho Geun-
dc.contributor.alternativeNameLee, Ok Hee-
dc.contributor.alternativeNameChoi, Kyung Chul-
dc.contributor.alternativeNameChoi, Hyo Kyoung-
dc.contributor.affiliatedAuthorKang, Hee Bum-
dc.contributor.affiliatedAuthorKim, Han Cheon-
dc.contributor.affiliatedAuthorYoon, Ho Geun-
dc.contributor.affiliatedAuthorLee, Ok Hee-
dc.contributor.affiliatedAuthorChoi, Kyung Chul-
dc.contributor.affiliatedAuthorChoi, Hyo Kyoung-
dc.contributor.affiliatedAuthorKim, Mi Jeong-
dc.citation.volume67-
dc.citation.number20-
dc.citation.startPage3499-
dc.citation.endPage3510-
dc.identifier.bibliographicCitationCELLULAR AND MOLECULAR LIFE SCIENCES, Vol.67(20) : 3499-3510, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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