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Identification of novel gastric cancer-associated CNVs by integrated analysis of microarray

DC FieldValueLanguage
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.contributor.author강승희-
dc.contributor.author기동혁-
dc.contributor.author노성훈-
dc.contributor.author라선영-
dc.contributor.author이원석-
dc.date.accessioned2015-04-23T17:03:07Z-
dc.date.available2015-04-23T17:03:07Z-
dc.date.issued2010-
dc.identifier.issn0022-4790-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101731-
dc.description.abstractBACKGROUND: Microarray-CGH facilitates analysis of cancer-associated genomic differences between normal and tumor tissues and provides a genome-wide assessment of copy number variations (CNVs). METHODS: To identify CNVs and their clinical significance in gastric cancer, Microarray-CGH was performed to identify CNVs with genomic DNA (gDNA) from normal placenta tissue, peripheral blood mononuclear cells (PBMCs), and normal gastric tissue. RESULTS: A total of 20 CNVs, including 8 novel CNVs, were identified by Microarray-CGH. Among the 20 CNVs, 5 showed an aberration frequency of over 50%. In addition, mRNA expression of W72437 (TFIIH), AI968311 (GAGE10), AI352361, and AA169807 (PTCH1) in normal tissues and AA485362 (GPX1), AI201652, and AI968311 (GAGE10) in cancer tissues was associated with DNA change. As a whole, incidences of oncogene-like, suppressor-like, and innocent CNVs were 13.8%, 13.2%, and 73.0%, respectively (gain 11.4%, loss 11.8%). AA936795 (C19orf61) appeared as an oncogene-like CNV (9/30, 30%), A1352361 (13/30, 43%), and AA281797 (LOC728340, 10/30, 33%) appeared as tumor suppressor-related CNVs. CONCLUSIONS: This study identified gastric cancer-associated and innocent CNVs in gDNA isolated from placenta tissue and PBMC, which are generally used as reference samples in Microarray-CGH. These novel CNVs may be used for gastric cancer-specific gene selection in comparative analysis of genomics.-
dc.description.statementOfResponsibilityopen-
dc.format.extent454~461-
dc.relation.isPartOfJOURNAL OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHFemale-
dc.subject.MESHGene Dosage*-
dc.subject.MESHGenes, Tumor Suppressor-
dc.subject.MESHGenome-
dc.subject.MESHHumans-
dc.subject.MESHLeukocytes, Mononuclear-
dc.subject.MESHMale-
dc.subject.MESHOligonucleotide Array Sequence Analysis/methods*-
dc.subject.MESHPlacenta-
dc.subject.MESHPregnancy-
dc.subject.MESHRNA, Messenger/analysis-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/metabolism-
dc.titleIdentification of novel gastric cancer-associated CNVs by integrated analysis of microarray-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorChan-Hee Park-
dc.contributor.googleauthorSun-Young Rha-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.contributor.googleauthorSeung-Hui Kang-
dc.contributor.googleauthorDong-Hyuk Ki-
dc.contributor.googleauthorWon-Suk Lee-
dc.contributor.googleauthorSung-Hoon Noh-
dc.contributor.googleauthorHyun-Cheol Chung-
dc.identifier.doi10.1002/jso.21585-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03773-
dc.contributor.localIdA00048-
dc.contributor.localIdA00274-
dc.contributor.localIdA01281-
dc.contributor.localIdA03001-
dc.contributor.localIdA03794-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ01762-
dc.identifier.eissn1096-9098-
dc.identifier.pmid20872948-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jso.21585/abstract-
dc.subject.keywordgastric cancer-
dc.subject.keywordcopy number variants-
dc.subject.keywordmicroarray‐CGH-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.alternativeNameKang, Seung Hui-
dc.contributor.alternativeNameKi, Dong Hyuk-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameLee, Won Suk-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorKang, Seung Hui-
dc.contributor.affiliatedAuthorKi, Dong Hyuk-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorLee, Won Suk-
dc.contributor.affiliatedAuthorJeung, Hei Cheul-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.citation.volume102-
dc.citation.number5-
dc.citation.startPage454-
dc.citation.endPage461-
dc.identifier.bibliographicCitationJOURNAL OF SURGICAL ONCOLOGY, Vol.102(5) : 454-461, 2010-
dc.identifier.rimsid46694-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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