Cited 10 times in
Identification of novel gastric cancer-associated CNVs by integrated analysis of microarray
DC Field | Value | Language |
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dc.contributor.author | 정현철 | - |
dc.contributor.author | 정희철 | - |
dc.contributor.author | 강승희 | - |
dc.contributor.author | 기동혁 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 이원석 | - |
dc.date.accessioned | 2015-04-23T17:03:07Z | - |
dc.date.available | 2015-04-23T17:03:07Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101731 | - |
dc.description.abstract | BACKGROUND: Microarray-CGH facilitates analysis of cancer-associated genomic differences between normal and tumor tissues and provides a genome-wide assessment of copy number variations (CNVs). METHODS: To identify CNVs and their clinical significance in gastric cancer, Microarray-CGH was performed to identify CNVs with genomic DNA (gDNA) from normal placenta tissue, peripheral blood mononuclear cells (PBMCs), and normal gastric tissue. RESULTS: A total of 20 CNVs, including 8 novel CNVs, were identified by Microarray-CGH. Among the 20 CNVs, 5 showed an aberration frequency of over 50%. In addition, mRNA expression of W72437 (TFIIH), AI968311 (GAGE10), AI352361, and AA169807 (PTCH1) in normal tissues and AA485362 (GPX1), AI201652, and AI968311 (GAGE10) in cancer tissues was associated with DNA change. As a whole, incidences of oncogene-like, suppressor-like, and innocent CNVs were 13.8%, 13.2%, and 73.0%, respectively (gain 11.4%, loss 11.8%). AA936795 (C19orf61) appeared as an oncogene-like CNV (9/30, 30%), A1352361 (13/30, 43%), and AA281797 (LOC728340, 10/30, 33%) appeared as tumor suppressor-related CNVs. CONCLUSIONS: This study identified gastric cancer-associated and innocent CNVs in gDNA isolated from placenta tissue and PBMC, which are generally used as reference samples in Microarray-CGH. These novel CNVs may be used for gastric cancer-specific gene selection in comparative analysis of genomics. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 454~461 | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Dosage* | - |
dc.subject.MESH | Genes, Tumor Suppressor | - |
dc.subject.MESH | Genome | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukocytes, Mononuclear | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis/methods* | - |
dc.subject.MESH | Placenta | - |
dc.subject.MESH | Pregnancy | - |
dc.subject.MESH | RNA, Messenger/analysis | - |
dc.subject.MESH | Stomach Neoplasms/genetics* | - |
dc.subject.MESH | Stomach Neoplasms/metabolism | - |
dc.title | Identification of novel gastric cancer-associated CNVs by integrated analysis of microarray | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Chan-Hee Park | - |
dc.contributor.googleauthor | Sun-Young Rha | - |
dc.contributor.googleauthor | Hei-Cheul Jeung | - |
dc.contributor.googleauthor | Seung-Hui Kang | - |
dc.contributor.googleauthor | Dong-Hyuk Ki | - |
dc.contributor.googleauthor | Won-Suk Lee | - |
dc.contributor.googleauthor | Sung-Hoon Noh | - |
dc.contributor.googleauthor | Hyun-Cheol Chung | - |
dc.identifier.doi | 10.1002/jso.21585 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A00048 | - |
dc.contributor.localId | A00274 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A03001 | - |
dc.contributor.localId | A03794 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J01762 | - |
dc.identifier.eissn | 1096-9098 | - |
dc.identifier.pmid | 20872948 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/jso.21585/abstract | - |
dc.subject.keyword | gastric cancer | - |
dc.subject.keyword | copy number variants | - |
dc.subject.keyword | microarray‐CGH | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.alternativeName | Kang, Seung Hui | - |
dc.contributor.alternativeName | Ki, Dong Hyuk | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Lee, Won Suk | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Kang, Seung Hui | - |
dc.contributor.affiliatedAuthor | Ki, Dong Hyuk | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Won Suk | - |
dc.contributor.affiliatedAuthor | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.citation.volume | 102 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 454 | - |
dc.citation.endPage | 461 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL ONCOLOGY, Vol.102(5) : 454-461, 2010 | - |
dc.identifier.rimsid | 46694 | - |
dc.type.rims | ART | - |
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