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The effects of COX-2 inhibitor during osteogenic differentiation of bone marrow-derived human mesenchymal stem cells.

DC Field Value Language
dc.contributor.author윤동석-
dc.contributor.author이진우-
dc.contributor.author한창동-
dc.contributor.author백승일-
dc.contributor.author유제현-
dc.contributor.author김윤희-
dc.date.accessioned2015-04-23T17:01:47Z-
dc.date.available2015-04-23T17:01:47Z-
dc.date.issued2010-
dc.identifier.issn1547-3287-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101689-
dc.description.abstractCyclooxygenase-2 (COX-2) inhibitors suppress bone repair and bone formation by suppressing angiogenesis as well as potentially interfering with osteoblast and osteoclast functions. In spite of these reports, there is a controversy over the exact effects of COX-2 inhibitors on bone formation processes itself. This work was designed to investigate the effect of COX-2 inhibitor on osteogenesis of human bone marrow-derived mesenchymal stem cells (MSC). MSCs in osteogenesis were treated with COX-2 inhibitor (celecoxib and naproxen) in the absence or presence of interleukin-1β (IL-1β), which was used to induce inflammation. Following differentiation, alkaline phosphatase (ALP) and calcium contents of IL-1β-treated MSC were significantly reduced by high doses of COX-2 inhibitors compared with the low-dose group. However, in non-inflammatory-conditioned MSCs, ALP and calcium contents were not reduced by COX-2 inhibitors. The mRNA expression of Runx2/Cbf alpha 1, Dlx5, and osteocalcin was also decreased by COX-2 inhibitors in inflammatory-conditioned MSCs and showed a significant decrease for the high dose while they remained constant in the non-inflammatory-conditioned MSCs. These data indicate that the osteogenic potential of MSC is inhibited/delayed by the treatment of high-dose NSAIDs under inflammatory conditions.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1523~1533-
dc.relation.isPartOfSTEM CELLS AND DEVELOPMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal/pharmacology-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal/therapeutic use-
dc.subject.MESHBiomarkers/metabolism-
dc.subject.MESHBone Marrow Cells/cytology-
dc.subject.MESHBone Marrow Cells/physiology*-
dc.subject.MESHCelecoxib-
dc.subject.MESHCell Differentiation/drug effects*-
dc.subject.MESHCyclooxygenase 2/metabolism*-
dc.subject.MESHCyclooxygenase 2 Inhibitors/pharmacology*-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHInflammation/chemically induced-
dc.subject.MESHInflammation/drug therapy-
dc.subject.MESHInflammation/genetics-
dc.subject.MESHInterleukin-1beta/pharmacology-
dc.subject.MESHMale-
dc.subject.MESHMesenchymal Stromal Cells/cytology-
dc.subject.MESHMesenchymal Stromal Cells/drug effects*-
dc.subject.MESHMesenchymal Stromal Cells/physiology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNaproxen/pharmacology-
dc.subject.MESHOsteogenesis/drug effects*-
dc.subject.MESHPyrazoles/pharmacology-
dc.subject.MESHRNA, Messenger/genetics-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHSulfonamides/pharmacology-
dc.subject.MESHYoung Adult-
dc.titleThe effects of COX-2 inhibitor during osteogenic differentiation of bone marrow-derived human mesenchymal stem cells.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학)-
dc.contributor.googleauthorDong Suk Yoon-
dc.contributor.googleauthorJe Hyun Yoo-
dc.contributor.googleauthorYun Hee Kim-
dc.contributor.googleauthorSeungil Paik-
dc.contributor.googleauthorChang Dong Han-
dc.contributor.googleauthorJin Woo Lee-
dc.identifier.doi10.1089/scd.2009.0393-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02547-
dc.contributor.localIdA03230-
dc.contributor.localIdA04330-
dc.contributor.localIdA01825-
dc.contributor.localIdA02509-
dc.contributor.localIdA00798-
dc.relation.journalcodeJ02684-
dc.identifier.eissn1557-8534-
dc.identifier.pmid20095820-
dc.identifier.urlhttp://online.liebertpub.com/doi/abs/10.1089/scd.2009.0393-
dc.contributor.alternativeNameYoon, Dong Suk-
dc.contributor.alternativeNameLee, Jin Woo-
dc.contributor.alternativeNameHan, Chang Dong-
dc.contributor.alternativeNamePaik, Seung Il-
dc.contributor.alternativeNameYoo, Je Hyun-
dc.contributor.alternativeNameKim, Yun Hee-
dc.contributor.affiliatedAuthorYoon, Dong Suk-
dc.contributor.affiliatedAuthorLee, Jin Woo-
dc.contributor.affiliatedAuthorHan, Chang Dong-
dc.contributor.affiliatedAuthorPaik, Seung Il-
dc.contributor.affiliatedAuthorYoo, Je Hyun-
dc.contributor.affiliatedAuthorKim, Yun Hee-
dc.citation.volume19-
dc.citation.number10-
dc.citation.startPage1523-
dc.citation.endPage1533-
dc.identifier.bibliographicCitationSTEM CELLS AND DEVELOPMENT, Vol.19(10) : 1523-1533, 2010-
dc.identifier.rimsid46667-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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