Cited 14 times in
Aurora-A kinase inhibition enhances the cytosine arabinoside-induced cell death in leukemia cells through apoptosis and mitotic catastrophe
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김수정 | - |
dc.contributor.author | 민유홍 | - |
dc.contributor.author | 엄주인 | - |
dc.contributor.author | 정준원 | - |
dc.contributor.author | 정회경 | - |
dc.date.accessioned | 2015-04-23T17:01:33Z | - |
dc.date.available | 2015-04-23T17:01:33Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101682 | - |
dc.description.abstract | Aurora-A (Aur-A) is a centrosome-associated serine/threonine kinase that is overexpressed in various cancers and potentially correlated with chemoresistance. In the Ara-C-sensitive leukemia cell lines, silencing of Aur-A by small interfering RNA transfection led to a significant increase in the Ara-C-induced cell death rate through induction of mitochondria-mediated, caspase-dependent apoptosis. In contrast, combined treatment of the Ara-C-resistant leukemia cell lines with Aur-A siRNA and Ara-C remarkably enhanced the cell death rate via non-caspase-dependent mitotic catastrophe. Taken together, Aur-A inhibition was an effective treatment for both the Ara-C-sensitive and resistant leukemia cells by increasing apoptosis and mitotic catastrophe, respectively. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 171~181 | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Aurora Kinases | - |
dc.subject.MESH | Caspases/metabolism | - |
dc.subject.MESH | Cell Cycle/drug effects | - |
dc.subject.MESH | Cell Death/drug effects | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Survival | - |
dc.subject.MESH | Cytarabine/pharmacology* | - |
dc.subject.MESH | HL-60 Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/drug therapy | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/enzymology | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/pathology | - |
dc.subject.MESH | Leukemia, Myeloid, Acute/therapy* | - |
dc.subject.MESH | Membrane Potential, Mitochondrial/drug effects | - |
dc.subject.MESH | Mitochondria/drug effects | - |
dc.subject.MESH | Mitochondria/genetics | - |
dc.subject.MESH | Mitochondria/metabolism | - |
dc.subject.MESH | Mitosis/drug effects | - |
dc.subject.MESH | Protein-Serine-Threonine Kinases/antagonists & inhibitors* | - |
dc.subject.MESH | Protein-Serine-Threonine Kinases/genetics | - |
dc.subject.MESH | RNA, Small Interfering/administration & dosage | - |
dc.subject.MESH | RNA, Small Interfering/genetics | - |
dc.subject.MESH | Transfection | - |
dc.subject.MESH | p38 Mitogen-Activated Protein Kinases/metabolism | - |
dc.title | Aurora-A kinase inhibition enhances the cytosine arabinoside-induced cell death in leukemia cells through apoptosis and mitotic catastrophe | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Haeng-Im Jung | - |
dc.contributor.googleauthor | Ju In Eom | - |
dc.contributor.googleauthor | Soo Jung Kim | - |
dc.contributor.googleauthor | Hoi-Kyung Jeung | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.identifier.doi | 10.1016/j.canlet.2010.05.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00633 | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A02338 | - |
dc.contributor.localId | A03729 | - |
dc.contributor.localId | A03787 | - |
dc.relation.journalcode | J00448 | - |
dc.identifier.eissn | 1872-7980 | - |
dc.identifier.pmid | 20547440 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304383510002855 | - |
dc.subject.keyword | Aurora kinase | - |
dc.subject.keyword | Acute leukemia | - |
dc.subject.keyword | Ara-C | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Mitotic catastrophe | - |
dc.contributor.alternativeName | Kim, Soo Jeong | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.alternativeName | Eom, Ju In | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.alternativeName | Jeung, Hoi Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Soo Jeong | - |
dc.contributor.affiliatedAuthor | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | Eom, Ju In | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.contributor.affiliatedAuthor | Jeung, Hoi Kyung | - |
dc.citation.volume | 297 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 171 | - |
dc.citation.endPage | 181 | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, Vol.297(2) : 171-181, 2010 | - |
dc.identifier.rimsid | 46663 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.