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Chemokine growth-regulated oncogene 1 as a putative biomarker for gastric cancer progression

DC FieldValueLanguage
dc.contributor.author노성훈-
dc.contributor.author노세원-
dc.contributor.author노재경-
dc.contributor.author라선영-
dc.contributor.author정민규-
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.date.accessioned2015-04-23T17:01:01Z-
dc.date.available2015-04-23T17:01:01Z-
dc.date.issued2010-
dc.identifier.issn1347-9032-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101665-
dc.description.abstractGastric cancer (GC) is a heterogeneous disease that is not well detected by current tumor markers. Identifying molecular markers that can predict the potential for tumor progression is important for appropriate individualized therapy. Using the Cancer Metastasis Research Center microarray database (17K cDNA microarray), we identified genes that were differentially expressed between 96 cancer and 98 normal gastric tissues using significant analysis of microarrays. From these, we selected genes that were overexpressed more than twofold in tumor tissues that encode secreted proteins. The selected genes were validated with ELISA using the sera of 96 GC patients and 48 healthy donors. Our first round of selection included 6510 genes that were differentially expressed between 96 cancer and 98 normal gastric tissues with a minimal false discovery rate of 0.005%. Out of those genes, we picked 386 that encoded secreted proteins based on the SOURCE database. Of these genes, we focused on 55 that were overexpressed more than twofold in GC compared to normal tissues. With Ingenuity Pathway Analysis, we found 34 genes related to cancer. One in particular, chemokine growth-regulated oncogene 1, CXCL1, has been linked to cancer progression in various cancer types, but not yet to GC. Levels of CXCL1 in serum samples of GC patients were significantly higher compared with healthy donors (P < 0.05). Within GC patients, CXCL1 serum levels increased according to tumor stage and lymph node metastasis. The CXCL1 gene appears to be a candidate marker for GC progression-
dc.description.statementOfResponsibilityopen-
dc.format.extent2200~2206-
dc.relation.isPartOfCANCER SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiomarkers, Tumor/blood*-
dc.subject.MESHChemokine CXCL1/blood*-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Profiling-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHStomach Neoplasms/blood-
dc.subject.MESHStomach Neoplasms/diagnosis*-
dc.subject.MESHStomach Neoplasms/mortality-
dc.subject.MESHStomach Neoplasms/pathology-
dc.titleChemokine growth-regulated oncogene 1 as a putative biomarker for gastric cancer progression-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJae-Joon Jung-
dc.contributor.googleauthorSewon Noh-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.contributor.googleauthorMinkyu Jung-
dc.contributor.googleauthorTae Soo Kim-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorJae Kyung Roh-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorSun Young Rha-
dc.identifier.doi10.1111/j.1349-7006.2010.01666.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01281-
dc.contributor.localIdA01282-
dc.contributor.localIdA01290-
dc.contributor.localIdA03606-
dc.contributor.localIdA03773-
dc.contributor.localIdA03794-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ00454-
dc.identifier.eissn1349-7006-
dc.identifier.pmid20731665-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2010.01666.x/abstract-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameNoh, Se Won-
dc.contributor.alternativeNameRoh, Jae Kyung-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameJung, Min Kyu-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorNoh, Se Won-
dc.contributor.affiliatedAuthorRoh, Jae Kyung-
dc.contributor.affiliatedAuthorJung, Min Kyu-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorJeung, Hei Cheul-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.citation.volume101-
dc.citation.number10-
dc.citation.startPage2200-
dc.citation.endPage2206-
dc.identifier.bibliographicCitationCANCER SCIENCE, Vol.101(10) : 2200-2206, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers

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