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Natural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction.

DC FieldValueLanguage
dc.contributor.author강은석-
dc.contributor.author김수현-
dc.contributor.author안덕선-
dc.contributor.author이용호-
dc.contributor.author이은직-
dc.contributor.author이현철-
dc.date.accessioned2015-04-23T17:00:20Z-
dc.date.available2015-04-23T17:00:20Z-
dc.date.issued2010-
dc.identifier.issn0008-6363-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101645-
dc.description.abstractAIMS: We have investigated the effects of magnesium lithospermate B (MLB), the active compound of the Oriental herbal remedy, Salvia miltiorrhizae, on endothelial dysfunction associated with diabetes mellitus using cultured endothelial cells and an animal model of type 2 diabetes mellitus. METHODS AND RESULTS: The effect of MLB on vasodilatory function in Otsuka Long-Evans Tokushima Fatty (OLETF) rats was assessed. MLB treatment for 20 weeks starting at 12 weeks attenuated the decrease in endothelium-dependent vasodilation in OLETF rats. MLB treatment also increased serum nitrite level and reduced serum advanced glycation end products concentration. The effect of MLB was greater than an equivalent dose of alpha-lipoic acid (alphaLA), a popular antioxidant treatment. MLB rescued the inhibition of endothelial nitric oxide synthase (eNOS) activity and eNOS phosphorylation in endothelial cells cultured in hyperglycaemia. This effect was dependent on Akt phosphorylation and associated with decreased O-linked N-acetylglucosamine protein modification of eNOS. MLB also increased nuclear factor erythroid 2-related factor-2 (Nrf-2) activation in a phosphoinositide 3-kinase/Akt pathway dependent manner. MLB treatment induced the expression of the Nrf-2-regulated antioxidant enzyme, heme oxygenase-1. The antioxidant alphaLA could not produce this effect. Moreover, MLB decreased oxidative stress and endothelial cell apoptosis caused by hyperglycaemia. CONCLUSION: MLB is a naturally occurring, new generation antioxidant that activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress. The relative strong performance of MLB makes it an ideal candidate for further, expanded trials as a new generation of antioxidant to treat diabetes-related complications.-
dc.description.statementOfResponsibilityopen-
dc.format.extent713~722-
dc.relation.isPartOfCARDIOVASCULAR RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntioxidants/pharmacology*-
dc.subject.MESHApoptosis/drug effects-
dc.subject.MESHCell Adhesion/drug effects-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDiabetes Mellitus, Type 2/complications-
dc.subject.MESHDiabetes Mellitus, Type 2/drug therapy*-
dc.subject.MESHDiabetes Mellitus, Type 2/metabolism-
dc.subject.MESHDiabetes Mellitus, Type 2/physiopathology-
dc.subject.MESHDiabetic Angiopathies/drug therapy*-
dc.subject.MESHDiabetic Angiopathies/etiology-
dc.subject.MESHDiabetic Angiopathies/metabolism-
dc.subject.MESHDiabetic Angiopathies/physiopathology-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHDrugs, Chinese Herbal/pharmacology*-
dc.subject.MESHEndothelium, Vascular/drug effects*-
dc.subject.MESHEndothelium, Vascular/metabolism-
dc.subject.MESHEndothelium, Vascular/pathology-
dc.subject.MESHEndothelium, Vascular/physiopathology-
dc.subject.MESHGlucose/metabolism*-
dc.subject.MESHGlycation End Products, Advanced/blood-
dc.subject.MESHGlycosylation-
dc.subject.MESHHeme Oxygenase-1/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHLeukocytes/drug effects-
dc.subject.MESHNF-E2-Related Factor 2/metabolism-
dc.subject.MESHNitric Oxide Synthase Type III/metabolism-
dc.subject.MESHNitrites/blood-
dc.subject.MESHOxidative Stress/drug effects-
dc.subject.MESHPhosphatidylinositol 3-Kinases/metabolism-
dc.subject.MESHPhosphorylation-
dc.subject.MESHProtein Processing, Post-Translational-
dc.subject.MESHProto-Oncogene Proteins c-akt/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Inbred OLETF-
dc.subject.MESHRats, Long-Evans-
dc.subject.MESHReactive Oxygen Species/metabolism-
dc.subject.MESHTime Factors-
dc.subject.MESHVasodilation/drug effects*-
dc.titleNatural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorSo Hun Kim-
dc.contributor.googleauthorSoo Hyun Kim-
dc.contributor.googleauthorMinah Choi-
dc.contributor.googleauthorYongho Lee-
dc.contributor.googleauthorYoung Ook Kim-
dc.contributor.googleauthorDuck Sun Ahn-
dc.contributor.googleauthorYoung Ho Kim-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorEun Jig Lee-
dc.contributor.googleauthorMankil Jung-
dc.contributor.googleauthorJin Won Cho-
dc.contributor.googleauthorDarren R.Williams-
dc.contributor.googleauthorHyun Chul Lee-
dc.identifier.doi10.1093/cvr/cvq089-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00068-
dc.contributor.localIdA02223-
dc.contributor.localIdA02989-
dc.contributor.localIdA03050-
dc.contributor.localIdA03301-
dc.contributor.localIdA00641-
dc.relation.journalcodeJ00464-
dc.identifier.eissn1755-3245-
dc.identifier.pmid20299332-
dc.subject.keywordDiabetes-
dc.subject.keywordEndothelial function-
dc.subject.keywordNitric oxide-
dc.subject.keywordAntioxidant-
dc.subject.keywordMagnesium lithospermate B-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Soo Hyun-
dc.contributor.alternativeNameAhn, Duk Sun-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameLee, Eun Jig-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorAhn, Duk Sun-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorLee, Eun Jig-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorKim, Soo Hyun-
dc.citation.volume87-
dc.citation.number4-
dc.citation.startPage713-
dc.citation.endPage722-
dc.identifier.bibliographicCitationCARDIOVASCULAR RESEARCH, Vol.87(4) : 713-722, 2010-
dc.identifier.rimsid40138-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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