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Risk Factors for Treatment Failure and Recurrence after Metronidazole Treatment for Clostridium difficile-associated Diarrhea

DC Field Value Language
dc.contributor.author전영은-
dc.contributor.author정규식-
dc.contributor.author정은석-
dc.contributor.author천재희-
dc.contributor.author홍성필-
dc.contributor.author김원호-
dc.contributor.author김태일-
dc.contributor.author문창모-
dc.contributor.author박재준-
dc.contributor.author신재국-
dc.contributor.author이경주-
dc.contributor.author이현정-
dc.contributor.author장희원-
dc.contributor.author전승민-
dc.contributor.author이상훈-
dc.date.accessioned2015-04-23T17:00:10Z-
dc.date.available2015-04-23T17:00:10Z-
dc.date.issued2010-
dc.identifier.issn1976-2283-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101640-
dc.description.abstractBACKGROUND/AIMS: The incidence of treatment failure or recurrence of Clostridium difficile-associated diarrhea (CDAD) following metronidazole treatment has increased recently. We studied the treatment failure, recurrence rate, and risk factors predictive of treatment failure and recurrence after metronidazole treatment for CDAD. METHODS: We retrospectively identified consecutive patients who were admitted and treated for CDAD at a single tertiary institution in Korea over a recent 10-year period (i.e., 1998-2008). RESULTS: Metronidazole was administered as the initial treatment to 111 of 117 patients (94.9%) with CDAD. Fourteen patients (12.6%) had no clinical response to the metronidazole treatment, and in 13 patients (13.4%) CDAD recurred after successful metronidazole treatment. Diabetes mellitus (p=0.014) and sepsis (p=0.002) were independent risk factors for metronidazole treatment failure. Patients who had received surgery within 1 month before CDAD developed were more likely to experience a recurrence after metronidazole treatment (p=0.032). Vancomycin exhibited a higher response rate after treatment failure, and metronidazole showed a reasonable response rate in the treatment of recurrence. Treatment failure and recurrence rates increased with time after metronidazole treatment for CDAD over the 10-year study period. CONCLUSIONS: Our data suggest that diabetes mellitus and sepsis are independent risk factors for metronidazole treatment failure, and that operation history within 1 month of development of CDAD is a predictor of a recurrence after metronidazole treatment.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfGUT AND LIVER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRisk Factors for Treatment Failure and Recurrence after Metronidazole Treatment for Clostridium difficile-associated Diarrhea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorKyu Sik Jung-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorYoung Eun Chon-
dc.contributor.googleauthorEun Suk Jung-
dc.contributor.googleauthorHyun Jung Lee-
dc.contributor.googleauthorHui Won Jang-
dc.contributor.googleauthorKyong Joo Lee-
dc.contributor.googleauthorSang Hoon Lee-
dc.contributor.googleauthorChang Mo Moon-
dc.contributor.googleauthorJin Ha Lee-
dc.contributor.googleauthorJae Kook Shin-
dc.contributor.googleauthorSoung Min Jeon-
dc.contributor.googleauthorSung Pil Hong-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.contributor.googleauthorJae Hee Cheon-
dc.identifier.doi10.5009/gnl.2010.4.3.332-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03532-
dc.contributor.localIdA03578-
dc.contributor.localIdA04404-
dc.contributor.localIdA00774-
dc.contributor.localIdA01079-
dc.contributor.localIdA01390-
dc.contributor.localIdA01636-
dc.contributor.localIdA02138-
dc.contributor.localIdA02656-
dc.contributor.localIdA03499-
dc.contributor.localIdA03526-
dc.contributor.localIdA04030-
dc.contributor.localIdA02836-
dc.contributor.localIdA03295-
dc.contributor.localIdA03686-
dc.relation.journalcodeJ00954-
dc.identifier.eissn2005-1212-
dc.identifier.pmid20981209-
dc.subject.keywordClostidium difficile-associated diarrhea-
dc.subject.keywordMetronidazole-
dc.subject.keywordVancomycin-
dc.contributor.alternativeNameChon, Young Eun-
dc.contributor.alternativeNameJung, Kyu Sik-
dc.contributor.alternativeNameJung, Eun Suk-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameHong, Sung Pil-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNameMoon, Chang Mo-
dc.contributor.alternativeNamePark, Jae Jun-
dc.contributor.alternativeNameShin, Jae Kook-
dc.contributor.alternativeNameLee, Kyong Joo-
dc.contributor.alternativeNameLee, Sang Hoon-
dc.contributor.alternativeNameLee, Hyun Jung-
dc.contributor.alternativeNameJang, Hui Won-
dc.contributor.alternativeNameJeon, Soung Min-
dc.contributor.affiliatedAuthorChon, Young Eun-
dc.contributor.affiliatedAuthorJung, Kyu Sik-
dc.contributor.affiliatedAuthorHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorMoon, Chang Mo-
dc.contributor.affiliatedAuthorPark, Jae Jun-
dc.contributor.affiliatedAuthorShin, Jae Kook-
dc.contributor.affiliatedAuthorLee, Kyong Joo-
dc.contributor.affiliatedAuthorJang, Hui Won-
dc.contributor.affiliatedAuthorJeon, Soung Min-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.contributor.affiliatedAuthorLee, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Hyun Jung-
dc.contributor.affiliatedAuthorJung, Eun Suk-
dc.citation.volume4-
dc.citation.number3-
dc.citation.startPage332-
dc.citation.endPage337-
dc.identifier.bibliographicCitationGUT AND LIVER, Vol.4(3) : 332-337, 2010-
dc.identifier.rimsid40136-
dc.type.rimsART-
Appears in Collections:
6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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