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Expression of antimicrobial peptides such as LL-37 and hBD-2 in nonlesional skin of atopic individuals.

Authors
 Jawoong Goo  ;  Jae Hong Ji  ;  Hyerin Jeon  ;  Min Jung Kim  ;  Soo-Young Jeon  ;  Mee-Yon Cho  ;  Seung Hun Lee  ;  Eung Ho Choi 
Citation
 PEDIATRIC DERMATOLOGY, Vol.27(4) : 341-348, 2010 
Journal Title
 PEDIATRIC DERMATOLOGY 
ISSN
 0736-8046 
Issue Date
2010
MeSH
Adolescent ; Antimicrobial Cationic Peptides/analysis ; Antimicrobial Cationic Peptides/metabolism* ; Child ; Dermatitis, Atopic/immunology* ; Foreskin ; Humans ; Interleukin-1alpha/analysis ; Interleukin-1alpha/metabolism* ; Male ; Skin/immunology* ; beta-Defensins/analysis ; beta-Defensins/metabolism*
Abstract
Recurrent skin infection is one of the major complications of atopic dermatitis and can be partly explained by decreased expression of antimicrobial peptides such as human beta-defensin-2 and cathelicidin (LL-37). In the human epidermis, human beta-defensin-2 is packed in the lamellar body and LL-37 is co-localized with intercellular lipid lamellae of the stratum corneum; together, these antimicrobial peptides constitute the primary defense system. IL-1alpha, a potent inducer of LL-37 and human beta-defensin-2, is also secreted from the disrupted epidermis for barrier homeostasis. In this study, we investigated whether expression of human beta-defensin-2 and LL-37 is constitutively decreased in the skin of atopic individuals. Nonlesional foreskins from atopic (n=7) and nonatopic (n=7) individuals were analyzed. The expression of LL-37, human beta-defensin-2 and IL-1alpha was analyzed using immunohistochemical staining, Western blot, and real-time polymerase chain reaction. Lamellar body density and secretion were evaluated by electron microscope. Quantitative analysis showed that the expression of each parameter was not significantly different between groups. Thus, basal expression of LL-37 and human beta-defensin-2 was not changed in atopic individuals. These results indicate that the expression of antimicrobial peptides at baseline was not different between nonlesional skin of atopic individuals and normal skin of nonatopic individuals
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1525-1470.2010.01122.x/abstract
DOI
10.1111/j.1525-1470.2010.01122.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Hun(이승헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101634
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