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Characteristics of complex fractionated atrial electrogram in the electroanatomically remodeled left atrium of patients with atrial fibrillation

 Jae Hyung Park  ;  Sang Weon Park  ;  Jong Youn Kim  ;  Sook Kyoung Kim  ;  Boyoung Jeoung  ;  Moon-Hyung Lee  ;  Chun Hwang  ;  Young-Hoon Kim  ;  Sung Soon Kim  ;  Hui-Nam Pak 
 CIRCULATION JOURNAL, Vol.74(8) : 1557-1563, 2010 
Journal Title
Issue Date
Adult ; Aged ; Atrial Fibrillation/pathology ; Atrial Fibrillation/physiopathology* ; Atrial Fibrillation/therapy* ; Body Surface Potential Mapping ; Catheter Ablation/methods* ; Electrophysiologic Techniques, Cardiac/methods* ; Female ; Heart Atria/pathology* ; Humans ; Male ; Middle Aged ; Treatment Outcome
Atrial fibrillation ; Computed tomography ; Left atrium ; Morphological remodeling ; Voltage mapping
BACKGROUND: Complex fractionated atrial electrogram (CFAE) guided ablation is effective in some patients with persistent atrial fibrillation (PeAF), but the pattern of CFAE may be different in the remodeled left atrium (LA). METHODS AND RESULTS: In 100 AF patients (83 males, 55.0+/-10.6 years old) with AF (51 paroxysmal AF (PAF), 49 PeAF) who underwent catheter ablation, CFAE cycle length (CL) and distribution (NavX 3D map) were compared according to the LA volume (3D-CT) and endocardial voltage (during high right atrial pacing 500-ms (Vol(PACE)) and AF (Vol(AF); NavX). The mean CFAE-CL was longer (P=0.003) and the % area CFAE was smaller (P=0.006) in patients with LA >or=125 ml than those with <125 ml. The mean CFAE-CL was longer in patients with Vol(PACE) <1.7 mV than those with >or=1.7 mV (P=0.002) and in Vol(AF) <0.7 mV than >or=0.7 mV (P<0.001). The % area CFAE was smaller in patients with Vol(PACE) <1.7 mV than those with >or=1.7 mV (P=0.006). The incidence of septal CFAE was consistently high, regardless of the degree of LA remodeling. CONCLUSIONS: In the AF patients with an electroanatomically remodeled LA, the % area of CFAE was smaller and mean CFAE-CL was longer than in those with a less remodeled LA. However, the majority of CFAE are consistently positioned on the septum in the remodeled LA.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soon(김성순)
Kim, Jong Youn(김종윤) ORCID logo https://orcid.org/0000-0001-7040-8771
Pak, Hui Nam(박희남) ORCID logo https://orcid.org/0000-0002-3256-3620
Lee, Moon Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
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