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Epidermal Hyperplasia and Elevated HB-EGF are More Prominent in Retinoid Dermatitis Compared with Irritant Contact Dermatitis Induced by Benzalkonium Chloride

Authors
 Jung Eun Lee  ;  Jae Yong Chang  ;  Sang Eun Lee  ;  Moon Young Kim  ;  Jeong Seon Lee  ;  Min Geol Lee  ;  Soo-Chan Kim 
Citation
 ANNALS OF DERMATOLOGY, Vol.22(3) : 290-299, 2010 
Journal Title
 ANNALS OF DERMATOLOGY 
ISSN
 1013-9087 
Issue Date
2010
MeSH
Animals ; Benzalkonium Compounds ; Cytokines ; Dermatitis ; Dermatitis, Contact ; Ear ; Epidermal Growth Factor ; Heparin ; Hyperplasia ; Intercellular Signaling Peptides and Proteins ; Interleukin-8 ; Intermediate Filament Proteins ; Membrane Proteins ; Mice ; Mice, Hairless ; Proliferating Cell Nuclear Antigen ; Prostaglandin-Endoperoxide Synthases ; Protein Precursors ; RNA, Messenger ; Skin ; Tumor Necrosis Factor-alpha ; Vitamin A ; Water Loss, Insensible
Keywords
Benzalkonium chloride ;  HB-EGF ;  Irritant contact dermatitis ;  Retinoid
Abstract
BACKGROUND: 'Retinoid dermatitis' is a retinoid-induced irritant contact dermatitis (ICD). The mechanism of retinoid dermatitis may be different from that of other ICDs. However, it remains uncertain how topical retinoid induce ICD. OBJECTIVE: We compared several aspects of contact dermatitis induced by topical retinol and benzalkonium chloride (BKC) on hairless mice skin. METHODS: 2% retinol or 2.5% BKC was applied to hairless mice and transepidermal water loss (TEWL), ear thickness, histologic and immunohistochemical findings were compared. We also compared mRNA expression of inflammatory cytokines, epidermal differential markers, cyclooxygenases (COXs) and heparin binding epidermal growth factor like growth factor (HB-EGF). RESULTS: Topical application of 2% retinol and 2.5% BKC increased TEWL and ear thickness in similar intensity. Epidermal hyperplasia was more prominent in retinol treated skin. Proliferating cell nuclear antigen, involucrin and loricrin expression were higher in retinol-treated skin than in BKC-treated skin. Filaggrin, however, was more expressed in BKC-treated skin. The mRNA expression of IL-8, TNF-alpha, COX-2, involucrin, loricrin and filaggrin were increased in both retinol- and BKC-treated skin in similar intensity. HB-EGF was more significantly increased in retinol-treated skin. CONCLUSION: Elevated HB-EGF and epidermal hyperplasia are more prominent features of retinoid dermatitis than in BKC-induced ICD
Files in This Item:
T201002282.pdf Download
DOI
10.5021/ad.2010.22.3.290
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Chan(김수찬) ORCID logo https://orcid.org/0000-0002-2327-4755
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
Lee, Sang Eun(이상은) ORCID logo https://orcid.org/0000-0003-4720-9955
Chang, Jae Yong(장재용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101508
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