Cited 8 times in
Down-regulated genes in mouse dental papillae and pulp
DC Field | Value | Language |
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dc.contributor.author | 권혁제 | - |
dc.contributor.author | 정한성 | - |
dc.date.accessioned | 2015-04-23T16:55:39Z | - |
dc.date.available | 2015-04-23T16:55:39Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101494 | - |
dc.description.abstract | Important factors involved in odontogenesis in mouse dental papillae disappear between the pre- and post-natal stages of development. Therefore, we hypothesized that certain genes involved in odontogenesis in dental papillae were subject to pre-/post-natal down-regulation. Our goal was to identify, by microarray analysis, which genes were down-regulated. Dental papillae were isolated from embryonic 16-day-, 18-day- (E16, E18), and post-natal 3-day-old (P3) murine first mandibular molar germs and analyzed by microarray. The number of down-regulated genes was 2269 between E16 and E18, and 3130 between E18 and P3. Drastic down-regulation (fold change > 10.0) of Adamts4, Aldha1a2, and Lef1 was observed at both E16 and E18, and quantitative RT-PCR revealed a post-natal reduction in their expression (Adamts4, 1/3; Aldh1a2, 1/13; and Lef1, 1/37). These results suggest that down-regulation of these three genes is an important factor in normal odontogenesis in dental papillae. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 679~683 | - |
dc.relation.isPartOf | JOURNAL OF DENTAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | ADAM Proteins/analysis | - |
dc.subject.MESH | ADAM Proteins/genetics | - |
dc.subject.MESH | ADAMTS4 Protein | - |
dc.subject.MESH | Aldehyde Dehydrogenase/analysis | - |
dc.subject.MESH | Aldehyde Dehydrogenase/genetics | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Death/genetics | - |
dc.subject.MESH | Dental Papilla/cytology* | - |
dc.subject.MESH | Dental Papilla/embryology | - |
dc.subject.MESH | Dental Pulp/cytology* | - |
dc.subject.MESH | Dental Pulp/embryology | - |
dc.subject.MESH | Down-Regulation/genetics* | - |
dc.subject.MESH | Epithelial Cells/cytology | - |
dc.subject.MESH | Gene Expression Regulation, Developmental/genetics | - |
dc.subject.MESH | In Situ Hybridization | - |
dc.subject.MESH | Lymphoid Enhancer-Binding Factor 1/analysis | - |
dc.subject.MESH | Lymphoid Enhancer-Binding Factor 1/genetics | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Odontoblasts/cytology | - |
dc.subject.MESH | Odontogenesis/genetics* | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Procollagen N-Endopeptidase/analysis | - |
dc.subject.MESH | Procollagen N-Endopeptidase/genetics | - |
dc.subject.MESH | Tooth Calcification/genetics | - |
dc.subject.MESH | Tooth Germ/cytology | - |
dc.subject.MESH | Tooth Germ/embryology | - |
dc.title | Down-regulated genes in mouse dental papillae and pulp | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | H. Sasaki | - |
dc.contributor.googleauthor | T. Muramatsu | - |
dc.contributor.googleauthor | H.-J. Kwon | - |
dc.contributor.googleauthor | H. Yamamoto | - |
dc.contributor.googleauthor | S. Hashimoto | - |
dc.contributor.googleauthor | H.-S. Jung | - |
dc.contributor.googleauthor | M. Shimono | - |
dc.identifier.doi | 10.1177/0022034510366844 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00261 | - |
dc.contributor.localId | A03758 | - |
dc.relation.journalcode | J01367 | - |
dc.identifier.eissn | 1544-0591 | - |
dc.identifier.pmid | 20448247 | - |
dc.identifier.url | http://jdr.sagepub.com/content/89/7/679.long | - |
dc.subject.keyword | dental papilla | - |
dc.subject.keyword | dental pulp | - |
dc.subject.keyword | odontogenesis | - |
dc.subject.keyword | gene expression | - |
dc.subject.keyword | tooth morphogenesis | - |
dc.contributor.alternativeName | Kwon, Hyuk Jae | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Kwon, Hyuk Jae | - |
dc.contributor.affiliatedAuthor | Jung, Han Sung | - |
dc.citation.volume | 89 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 679 | - |
dc.citation.endPage | 683 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DENTAL RESEARCH, Vol.89(7) : 679-683, 2010 | - |
dc.identifier.rimsid | 47770 | - |
dc.type.rims | ART | - |
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