Cited 578 times in
Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles
DC Field | Value | Language |
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dc.contributor.author | 김은숙 | - |
dc.contributor.author | 신전수 | - |
dc.date.accessioned | 2015-04-23T16:54:16Z | - |
dc.date.available | 2015-04-23T16:54:16Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101449 | - |
dc.description.abstract | Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produced. A novel material that incorporates zinc-doped iron oxide nanocrystals within a mesoporous silica framework that has been surface-modified with pseudorotaxanes is described. Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. This material promises to be a noninvasive, externally controlled drug delivery system with cancer-killing properties. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 10623~10625 | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antineoplastic Agents/chemistry* | - |
dc.subject.MESH | Antineoplastic Agents/metabolism* | - |
dc.subject.MESH | Antineoplastic Agents/pharmacokinetics | - |
dc.subject.MESH | Cell Death/drug effects | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Doxorubicin/chemistry* | - |
dc.subject.MESH | Doxorubicin/metabolism* | - |
dc.subject.MESH | Doxorubicin/pharmacokinetics | - |
dc.subject.MESH | Drug Delivery Systems* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetics* | - |
dc.subject.MESH | Nanoparticles/chemistry* | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Porosity | - |
dc.subject.MESH | Silicon Dioxide/chemistry | - |
dc.subject.MESH | Surface Properties | - |
dc.title | Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Courtney R. Thomas | - |
dc.contributor.googleauthor | Daniel P. Ferris | - |
dc.contributor.googleauthor | Jae-Hyun Lee | - |
dc.contributor.googleauthor | Eunjoo Choi | - |
dc.contributor.googleauthor | Mi Hyeon Cho | - |
dc.contributor.googleauthor | Eun Sook Kim | - |
dc.contributor.googleauthor | J. Fraser Stoddart | - |
dc.contributor.googleauthor | Jeon-Soo Shin | - |
dc.contributor.googleauthor | Jinwoo Cheon | - |
dc.contributor.googleauthor | Jeffrey I. Zink | - |
dc.identifier.doi | 10.1021/ja1022267 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02144 | - |
dc.contributor.localId | A00808 | - |
dc.relation.journalcode | J01769 | - |
dc.identifier.eissn | 1520-5126 | - |
dc.identifier.pmid | 20681678 | - |
dc.identifier.url | http://pubs.acs.org/doi/abs/10.1021/ja1022267 | - |
dc.contributor.alternativeName | Kim, Eun Sook | - |
dc.contributor.alternativeName | Shin, Jeon Soo | - |
dc.contributor.affiliatedAuthor | Shin, Jeon Soo | - |
dc.contributor.affiliatedAuthor | Kim, Eun Sook | - |
dc.citation.volume | 132 | - |
dc.citation.number | 31 | - |
dc.citation.startPage | 10623 | - |
dc.citation.endPage | 10625 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.132(31) : 10623-10625, 2010 | - |
dc.identifier.rimsid | 51063 | - |
dc.type.rims | ART | - |
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