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Characteristics of clinical isolates of Acinetobacter genomospecies 10 carrying two different metallo-beta-lactamases.

Authors
 Kyungwon Lee  ;  Chang Ki Kim  ;  Seong Geun Hong  ;  Jonghyeon Choi  ;  Sungwook Song  ;  Eunmi Koh  ;  Dongeun Yong  ;  Seok Hoon Jeong  ;  Jong Hwa Yum  ;  Jean-Denis Docquier  ;  Gian Maria Rossolini  ;  Yunsop Chong 
Citation
 INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, Vol.36(3) : 259-263, 2010 
Journal Title
 INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 
ISSN
 0924-8579 
Issue Date
2010
MeSH
Acinetobacter/classification ; Acinetobacter/enzymology* ; Acinetobacter/genetics* ; Acinetobacter/isolation & purification ; Acinetobacter Infections/microbiology* ; Adult ; Aged ; Anti-Bacterial Agents/pharmacology* ; Bacterial Proteins/biosynthesis* ; Bacterial Proteins/genetics ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Molecular Sequence Data ; Sequence Analysis, DNA ; beta-Lactamases/biosynthesis* ; beta-Lactamases/genetics ; beta-Lactams/pharmacology*
Abstract
Acquired metallo-beta-lactamase (MBL) production is an important mechanism of carbapenem resistance. To our knowledge, carriage of two different MBLs has not been described previously in Acinetobacter spp. We present the characteristics of five Acinetobacter isolates carrying two different MBL genes. The species of all five Acinetobacter isolates with two different MBL genes were Acinetobacter genomospecies 10, and bla(IMP-1), bla(VIM-2) and bla(SIM-1) may coexist in this species. Minimum inhibitory concentrations (MICs) of imipenem for all five isolates with two different MBLs were >or=32 microg/mL, whilst those for two segregants that lost both MBLs were 0.5 microg/mL. The presence of MBL gene-carrying integrons with identical structures suggested the easily transferable nature of the elements, whilst instability of the MBL genes indicated potentially erroneous phenotypic and genetic characterisation.
Full Text
http://www.sciencedirect.com/science/article/pii/S0924857910002372
DOI
10.1016/j.ijantimicag.2010.05.018
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Eun Mi(고은미)
Kim, Chang Ki(김창기)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Chong, Yun Sop(정윤섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101286
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