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Predictive factors of isolated distant metastasis after primary definitive surgery without systemic treatment for head and neck squamous cell carcinoma

 Jae-Yol Lim  ;  Young Chang Lim  ;  Se-Heon Kim  ;  Jae Wook Kim  ;  Ha Min Jeong  ;  Eun Chang Choi 
 ORAL ONCOLOGY, Vol.46(7) : 504-508, 2010 
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Adult ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/secondary* ; Cohort Studies ; Disease-Free Survival ; Female ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/pathology* ; Humans ; Male ; Middle Aged ; Neoplasm, Residual ; Predictive Value of Tests ; Retrospective Studies ; Salvage Therapy
Incidence of isolated distant metastasis (IDM) was relatively low in patients who achieved locoregional control after primary definitive surgery. However, the prognosis of patients with IDM was dismal. The aim of this study was to evaluate the clinical outcome of patients with IDM and identify independent predictive factors of IDM after primary definitive surgery for head and neck squamous cell carcinoma (HNSCC). A retrospective data review was conducted for 795 patients who underwent primary definitive surgery without any systemic treatment for squamous cell carcinoma (SCC) of the oral cavity, oropharynx, larynx, and hypopharynx. Distant metastasis-free survival was calculated and independent predictive factors for IDM were determined by Cox proportional-hazards model. For the entire study cohort, IDM developed in 75 patients (9.4%). Among 631 patients who achieved locoregional control, IDM occurred in 44 patients (7%). The median time to IDM after primary surgery was 13months, ranging from 2 to 70months. The overall salvage rate was 9% (4 of 44) after salvage treatment for IDM. In the Cox proportional-hazards model, clinical N status, and histological grade were independent predictive factors of IDM. Patients who had clinically palpable neck disease and a histologically poor grade were more likely to develop IDM after primary definitive surgery. Patients with these factors should be considered candidates for proper adjuvant systemic treatment and evaluated more thoroughly for early detection of IDM during follow-up
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Heon(김세헌)
Lim, Jae Yol(임재열) ORCID logo https://orcid.org/0000-0002-9757-6414
Jeong, Ha Min(정하민)
Choi, Eun Chang(최은창)
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