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Parathyroid carcinoma: a 16-year experience in a single institution

Authors
 Yong Sang Lee  ;  Soon Won Hong  ;  Jong Ju Jeong  ;  Kee-Hyun Nam  ;  Woong Youn Chung  ;  Hang-Seok Chang  ;  Cheong Soo Park 
Citation
 ENDOCRINE JOURNAL, Vol.57(6) : 493-497, 2010 
Journal Title
ENDOCRINE JOURNAL
ISSN
 0918-8959 
Issue Date
2010
MeSH
Adult ; Calcium/blood ; Female ; Humans ; Male ; Middle Aged ; Parathyroid Hormone/blood ; Parathyroid Neoplasms/diagnosis* ; Parathyroid Neoplasms/surgery ; Parathyroidectomy ; Technetium Tc 99m Sestamibi ; Tomography, X-Ray Computed
Abstract
INTRODUCTION: This study aims to describe our experiences of parathyroid carcinoma. MATERIALS AND METHODS: The data of clinicopathological features, surgical treatment and outcomes of seven cases of parathyroid carcinoma among 171 patients who underwent surgery for primary hyperparathyroidism over a 16-year period were analyzed. RESULTS: The major symptoms at the diagnosis included a neck mass in three cases and multiple bone pain in five. Two patients were asymptomatic. No remarkable increases of serum calcium levels were noted in the patients, but serum parathyroid hormone (PTH) concentrations were high in most of the patients (4 of 5 in available). A variety of imaging studies including ultrasonography, sestamibi scan, and computed tomography scan were helpful in identifying the abnormal parathyroid glands, but not specific for the diagnosis of parathyroid carcinoma. In most patients, the parathyroid carcinomas were suspected at the time of neck exploration, and confirmed by final histopathologic examinations. All patients underwent complete surgical excision with curative intent. During the follow-up period, one patient developed lung metastases 6 years later and the other one died of unrelated cause. CONCLUSION: Preoperative diagnosis of parathyroid carcinoma is difficult, but operative findings are helpful in the diagnosis. The optimal surgical treatment is en block radical resection including adjacent structures when parathyroid carcinoma is suspected. Unusually, although our patients presented with high serum PTH concentrations, they had normal or mild elevated serum calcium concentrations. The reason of why should be investigated in future studies.
Files in This Item:
T201001843.pdf Download
DOI
10.1507/endocrj.K09E-365
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
Lee, Yong Sang(이용상) ORCID logo https://orcid.org/0000-0002-8234-8718
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
Chung, Woong Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101214
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