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Development of aggressive squamous cell carcinoma in epidermodysplasia verruciformis associated with human papillomavirus type 22b

Authors
 Kim T.  ;  Park J.C.  ;  Roh M.R.  ;  Park J.M.  ;  Kim S.H.  ;  Cho N.H.  ;  Lee M.-G. 
Citation
 DERMATOLOGY, Vol.220(4) : 326-328, 2010 
Journal Title
DERMATOLOGY
ISSN
 1018-8665 
Issue Date
2010
MeSH
Adult ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/therapy ; Carcinoma, Squamous Cell/virology* ; Epidermodysplasia Verruciformis/complications* ; Epidermodysplasia Verruciformis/genetics ; Humans ; Male ; Nose Neoplasms/pathology ; Nose Neoplasms/therapy ; Nose Neoplasms/virology* ; Papillomaviridae/classification ; Papillomaviridae/isolation & purification* ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy ; Skin Neoplasms/virology*
Abstract
Epidermodysplasia verruciformis (EV) is a rare genetic disease characterized by abnormal susceptibility to infection with EV-related human papillomavirus (HPV), now known as the beta-papillomavirus (beta-PV). Clinically specific beta-PV-type-associated EV, especially HPV-5 and -8, shows a high rate of progression to squamous cell carcinoma (SCC). In this report, we describe a 39-year-old Korean man with HPV-22b-associated EV who developed a rapidly progressing SCC. The patient presented with a huge destructive mass on the nose. Histopathological evaluation of the mass was compatible with well-differentiated SCC. HPV typing results from both EV and SCC specimens demonstrated HPV-22b which has not been considered to be associated with SCC in EV patients so far. The patient underwent surgical excision and postoperative radiotherapy for locoregional control. This is the first report presenting the association of an SCC arising from previous EV with HPV-22b infection only.
Full Text
http://www.karger.com/Article/FullText/290759
DOI
10.1159/000290759
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101211
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