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New cfiA variant and novel insertion sequence elements in carbapenem-resistant Bacteroides fragilis isolates from Korea.

DC Field Value Language
dc.contributor.author김신영-
dc.contributor.author김준명-
dc.contributor.author용동은-
dc.contributor.author이경원-
dc.contributor.author정석훈-
dc.contributor.author정윤섭-
dc.date.accessioned2015-04-23T16:46:12Z-
dc.date.available2015-04-23T16:46:12Z-
dc.date.issued2010-
dc.identifier.issn0732-8893-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101191-
dc.description.abstractOf 276 nonduplicate Bacteroides fragilis clinical isolates recovered from 1997 to 2004, 3 were resistant to carbapenem. cepA and cfiA alleles were detected by polymerase chain reaction in 240 (87.0%) and 11 (4.0%) of the isolates, respectively. Insertion sequence (IS) elements were found only in the 3 carbapenem-resistant B. fragilis isolates, which produced metallo-beta-lactamase at a level detectable by UV spectrophotometry. Sequence analysis showed 1 new cfiA variant, cfiA(11), and 2 novel IS elements. The cfiA(11) gene revealed 5 amino acid substitutions compared to cfiA, with 97.6% amino acid identity. The transposase, terminal inverted repeat sequence, and target site duplication sequence of the 2 novel IS elements were unique. This study reconfirmed the correlation between ISs and carbapenem resistance in B. fragilis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent343~348-
dc.relation.isPartOfDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAmino Acid Sequence-
dc.subject.MESHAmino Acid Substitution/genetics-
dc.subject.MESHAnti-Bacterial Agents/pharmacology*-
dc.subject.MESHBacterial Proteins/biosynthesis-
dc.subject.MESHBacterial Proteins/genetics*-
dc.subject.MESHBacteroides Infections/microbiology-
dc.subject.MESHBacteroides fragilis/drug effects*-
dc.subject.MESHBacteroides fragilis/genetics*-
dc.subject.MESHBacteroides fragilis/isolation & purification-
dc.subject.MESHCarbapenems/pharmacology*-
dc.subject.MESHDNA Transposable Elements*-
dc.subject.MESHDNA, Bacterial/chemistry-
dc.subject.MESHDNA, Bacterial/genetics-
dc.subject.MESHHumans-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSequence Alignment-
dc.subject.MESHSequence Analysis, DNA-
dc.subject.MESHSequence Homology, Amino Acid-
dc.subject.MESHbeta-Lactam Resistance*-
dc.subject.MESHbeta-Lactamases/biosynthesis-
dc.subject.MESHbeta-Lactamases/genetics*-
dc.titleNew cfiA variant and novel insertion sequence elements in carbapenem-resistant Bacteroides fragilis isolates from Korea.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorKyoung Ho Roh-
dc.contributor.googleauthorSinyoung Kim-
dc.contributor.googleauthorChang-Ki Kim-
dc.contributor.googleauthorJong Hwa Yum-
dc.contributor.googleauthorMyung Sook Kim-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorKyungwon Lee-
dc.contributor.googleauthorJune Myung Kim-
dc.contributor.googleauthorYunsop Chong-
dc.identifier.doi10.1016/j.diagmicrobio.2009.11.003-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00675-
dc.contributor.localIdA00953-
dc.contributor.localIdA02423-
dc.contributor.localIdA02649-
dc.contributor.localIdA03619-
dc.contributor.localIdA03679-
dc.relation.journalcodeJ00731-
dc.identifier.eissn1879-0070-
dc.identifier.pmid20226324-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0732889309004490-
dc.contributor.alternativeNameKim, Sin Young-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.alternativeNameChong, Yun Sop-
dc.contributor.affiliatedAuthorKim, Sin Young-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorYong, Dong Eun-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.contributor.affiliatedAuthorChong, Yun Sop-
dc.citation.volume66-
dc.citation.number4-
dc.citation.startPage343-
dc.citation.endPage348-
dc.identifier.bibliographicCitationDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.66(4) : 343-348, 2010-
dc.identifier.rimsid52123-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
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