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Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail.

Authors
 Y Xu  ;  S-H Lee  ;  H S Kim  ;  N H Kim  ;  S Piao  ;  S-H Park  ;  Y S Jung  ;  J I Yook  ;  B-J Park  ;  N-C Ha 
Citation
 ONCOGENE, Vol.29(21) : 3124-3133, 2010 
Journal Title
ONCOGENE
ISSN
 0950-9232 
Issue Date
2010
MeSH
Binding Sites ; Creatine Kinase/metabolism ; Glutathione Transferase/metabolism ; Glycogen Synthase Kinase 3/metabolism* ; Glycogen Synthase Kinase 3 beta ; Humans ; Isoenzymes/metabolism ; Kinetics ; Phosphorylation ; Phosphoserine/metabolism ; RNA, Small Interfering/metabolism ; Snail Family Transcription Factors ; Substrate Specificity ; Transcription Factors/metabolism* ; beta-Transducin Repeat-Containing Proteins/metabolism
Abstract
The epithelial to mesenchymal transition (EMT) that occurs during embryonic development has begun to attract attention as a potential mechanism for tumor cell metastasis. Snail is a well-known Zn-finger transcription factor that promotes EMT by repressing E-cadherin expression. It is known that Snail is phosphorylated by GSK3beta and degraded by beta-TrCP-mediated ubiquitination. Here we described another protein kinase, CK1, whose phosphorylation of Snail is required for the subsequent GSK3beta phosphorylation. Specific inhibition or depletion of CK1varepsilon inhibits the phosphorylation and degradation of Snail and promotes cell migration, suggesting a central role of CK1varepsilon in the EMT process. Furthermore, our study uncovered distinct roles and steps of Snail phosphorylation by CK1varepsilon and GSK3beta. Taken together, we identified CK1varepsilon as a new component of the Snail-mediated EMT process, providing insight into the mechanism of human cancer metastasis
Full Text
http://www.nature.com/onc/journal/v29/n21/full/onc201077a.html
DOI
10.1038/onc.2010.77
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Hee(김남희) ORCID logo https://orcid.org/0000-0002-3087-5276
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101106
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