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Helicobacter pylori in a Korean isolate expressed proteins differentially in human gastric epithelial cells

DC FieldValueLanguage
dc.contributor.author김경환-
dc.date.accessioned2015-04-23T16:42:43Z-
dc.date.available2015-04-23T16:42:43Z-
dc.date.issued2010-
dc.identifier.issn0163-2116-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101082-
dc.description.abstractPURPOSE: The proteins expressed in gastric epithelial cells infected with Helicobacter pylori (H. pylori) may determine the clinical outcome such as chronic gastritis, peptic ulcer, and gastric carcinoma. The present study aims to determine the differentially expressed proteins in human gastric epithelial AGS cells that were infected with H. pylori in a Korean isolate, a cagA+, vacA s1b m2 iceA1 H. pylori by proteomic analysis. The differentially expressed proteins, whose expression levels were more or less than twofold in H. pylori-infected cells, were analyzed. RESULTS: Ten proteins (chromatin assembly factor-1, proliferating cell nuclear antigen, 14-3-3 protein tau, eukaryotic translation initiation factor 6, heat-shock protein 90beta, dimethylarginine dimethylaminohydrolase-1, L-lactate dehydrogenase B chain, prohibitin, triosephosphate isomerase, protein disulfide isomerase) were up-regulated while eight proteins (heat-shock gp96 precursor, nucleophosmin, ornithine aminotransferase, Ku70, L-arginine-glycine amidinotransferase, Smad anchor for receptor activation, ADP-ribosylation factor, WD repeat-containing protein isoform 1) were down-regulated by H. pylori infection in AGS cells. These proteins are related to cell proliferation, cell adhesion, carcinogenesis, cell-defense mechanisms against oxidative stress, membrane trafficking, and energy metabolism. CONCLUSIONS: Oxidative stress, cell proliferation, cell adhesion, and membrane trafficking may be involved in the pathogenesis of gastric diseases including cancer associated with H. pylori in a Korean isolate.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1550~1564-
dc.relation.isPartOfDIGESTIVE DISEASES AND SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/microbiology-
dc.subject.MESHAdenocarcinoma/pathology-
dc.subject.MESHBacterial Proteins/metabolism*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHElectrophoresis, Gel, Two-Dimensional-
dc.subject.MESHEpithelial Cells/microbiology*-
dc.subject.MESHEpithelial Cells/pathology-
dc.subject.MESHGastric Mucosa/microbiology*-
dc.subject.MESHGastric Mucosa/pathology-
dc.subject.MESHHelicobacter Infections/epidemiology-
dc.subject.MESHHelicobacter Infections/microbiology*-
dc.subject.MESHHelicobacter pylori/isolation & purification-
dc.subject.MESHHelicobacter pylori/metabolism-
dc.subject.MESHHelicobacter pylori/pathogenicity*-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHProteomics/methods-
dc.subject.MESHSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization-
dc.subject.MESHStomach Neoplasms/microbiology-
dc.subject.MESHStomach Neoplasms/pathology-
dc.titleHelicobacter pylori in a Korean isolate expressed proteins differentially in human gastric epithelial cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorSung Hee Lee-
dc.contributor.googleauthorMin-Soo Lee-
dc.contributor.googleauthorJi Hyun Lee-
dc.contributor.googleauthorSo Won Kim-
dc.contributor.googleauthorRhee-Hun Kang-
dc.contributor.googleauthorMyoung-Jin Choi-
dc.contributor.googleauthorSang Jin Park-
dc.contributor.googleauthorSe Joo Kim-
dc.contributor.googleauthorJae Myun Lee-
dc.contributor.googleauthorSusan P.C. Cole-
dc.contributor.googleauthorMin Goo Lee-
dc.identifier.doi10.1007/s10620-009-0908-z-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00311-
dc.relation.journalcodeJ00737-
dc.identifier.eissn1573-2568-
dc.identifier.pmid19672714-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs10620-009-0908-z-
dc.subject.keywordGastric epithelial cells-
dc.subject.keywordGastroduodenal disease-
dc.subject.keywordHelicobacter pylori-
dc.subject.keywordProteomic analysis-
dc.contributor.alternativeNameKim, Kyung Hwan-
dc.contributor.affiliatedAuthorKim, Kyung Hwan-
dc.citation.volume55-
dc.citation.number6-
dc.citation.startPage1550-
dc.citation.endPage1564-
dc.identifier.bibliographicCitationDIGESTIVE DISEASES AND SCIENCES, Vol.55(6) : 1550-1564, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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