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Retinyl retinoate induces hyaluronan production and less irritation than other retinoids

Authors
 Jin Eun KIM  ;  Bora KIM  ;  Hyuk KIM  ;  Hyojung KIM  ;  Joo Dong LEE  ;  Hyun Jung KIM  ;  Kang Yell CHOI  ;  Seung Hun LEE 
Citation
 JOURNAL OF DERMATOLOGY, Vol.37(5) : 448-454, 2010 
Journal Title
 JOURNAL OF DERMATOLOGY 
ISSN
 0385-2407 
Issue Date
2010
MeSH
Administration, Topical ; Animals ; Epidermis/metabolism* ; Female ; Glucuronosyltransferase/metabolism ; Humans ; Hyaluronan Receptors/metabolism ; Hyaluronan Synthases ; Hyaluronic Acid/biosynthesis* ; Irritants ; Keratinocytes/drug effects* ; Keratinocytes/metabolism ; Mice ; Mice, Hairless ; Retinoids/adverse effects ; Retinoids/pharmacology* ; Reverse Transcriptase Polymerase Chain Reaction ; Up-Regulation
Keywords
hyaluronan ; hyaluronan synthase 2 ; retinyl retinoate ; transepidermal water loss
Abstract
Hyaluronan, a non-sulfated glycosaminoglycan, retains water, maintains the extracellular spaces and facilitates the transport of ion solutes and nutrients. Hyaluronan is closely involved in keratinocyte proliferation, migration and differentiation. The synthesis of hyaluronan in vitro can be stimulated by several growth factors, including retinoids, dibutyryl cyclic adenosine monophosphate and peroxisome proliferator-activated receptor-alpha agonist. In this study, we examined retinyl retinoate (a novel retinol derivative) on hyaluronan expression in primary human keratinocytes and in hairless mouse epidermal skin. Histochemistry using hyaluronan-binding protein revealed that topical retinyl retinoate increased the intensity of hyaluronan staining in murine skin. Moreover, topical retinyl retinoate increased CD44 (hyaluronan receptor) expression. Using reverse transcription polymerase chain reaction, we assessed the expression level of the hyaluronan synthase 2 (HAS2) gene in primary human keratinocytes and in hairless mouse epidermal skin. We found that retinyl retinoate upregulated mouse HAS2 and human HAS2 mRNA. Application of retinyl retinoate induced increasing transepidermal water loss less than retinol, retinoic acid and retinaldehyde. Taken together, we suggest that retinyl retinoate is more effective on hyaluronan production and less of an irritant than other retinoids
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1346-8138.2010.00808.x/abstract
DOI
10.1111/j.1346-8138.2010.00808.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Hun(이승헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101068
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