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Chromatin organization and transcriptional activation of Hox genes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김명희 | - |
dc.contributor.author | 민혜현 | - |
dc.contributor.author | 이지연 | - |
dc.date.accessioned | 2015-04-23T16:40:09Z | - |
dc.date.available | 2015-04-23T16:40:09Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 2093-3665 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101003 | - |
dc.description.abstract | Spatially and temporally programmed expression of the Hox genes along the antero-posterior (A-P) axis is essential for correct pattern formation during embryonic development. An accumulating body of evidence indicates the pivotal role of spatial chromatin organization for the coordination of gene regulation. Recently, chromosome conformation capture (3C) technique has been developed and opened a new way to study chromosomal interactions in the nucleus. In this study, we describe 3C method we applied in F9 embryonic teratocarcinoma cells and demonstrate that the chromosomal interactions at Hox loci are successfully detected. Interestingly, at Hoxc loci, the abundance of intrachromosomal interactions with neighboring fragments was drastically decreased when the genes are expressed. These results indicate the possibility of the dynamic pattern of chromosomal interaction in association with the transcriptional regulation of Hox genes | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 78~85 | - |
dc.relation.isPartOf | Anatomy and Cell Biology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Chromatin organization and transcriptional activation of Hox genes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학) | - |
dc.contributor.googleauthor | Ji-Yeon Lee | - |
dc.contributor.googleauthor | Hyehyun Min | - |
dc.contributor.googleauthor | Xinnan Wang | - |
dc.contributor.googleauthor | Abdul Aziz Khan | - |
dc.contributor.googleauthor | Myoung Hee Kim | - |
dc.identifier.doi | 10.5115/acb.2010.43.1.78 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00432 | - |
dc.contributor.localId | A01416 | - |
dc.contributor.localId | A03194 | - |
dc.relation.journalcode | J00142 | - |
dc.identifier.pmid | 21190008 | - |
dc.subject.keyword | Hox genes | - |
dc.subject.keyword | chromosomal interaction | - |
dc.subject.keyword | chromosome conformation capture | - |
dc.subject.keyword | gene expression | - |
dc.subject.keyword | spatial organization | - |
dc.contributor.alternativeName | Kim, Myoung Hee | - |
dc.contributor.alternativeName | Min, Hye Hyun | - |
dc.contributor.alternativeName | Lee, Ji Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Hee | - |
dc.contributor.affiliatedAuthor | Min, Hye Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Ji Yeon | - |
dc.citation.volume | 43 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 78 | - |
dc.citation.endPage | 85 | - |
dc.identifier.bibliographicCitation | Anatomy and Cell Biology, Vol.43(1) : 78-85, 2010 | - |
dc.identifier.rimsid | 54503 | - |
dc.type.rims | ART | - |
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