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Treatment of generalized hyperhidrosis with oxybutynin in post-menopausal patients

Authors
 Won Oak Kim  ;  Hae Keum Kil  ;  Kyung Bong Yoon  ;  Ji Hyun Yoo 
Citation
 ACTA DERMATO-VENEREOLOGICA, Vol.90(3) : 291-293, 2010 
Journal Title
 ACTA DERMATO-VENEREOLOGICA 
ISSN
 0001-5555 
Issue Date
2010
MeSH
Female ; Humans ; Hyperhidrosis/drug therapy* ; Hyperhidrosis/physiopathology ; Mandelic Acids/adverse effects ; Mandelic Acids/therapeutic use* ; Middle Aged ; Muscarinic Antagonists/adverse effects ; Muscarinic Antagonists/therapeutic use* ; Postmenopause ; Prospective Studies ; Quality of Life ; Severity of Illness Index ; Surveys and Questionnaires ; Sweating/drug effects* ; Time Factors ; Treatment Outcome
Abstract
Postmenopausal hyperhidrosis is a form of secondary hyperhidrosis, and hormone-replacement therapy is a commonly used therapeutic option. However, some women do not benefit from this treatment, and oral anticholinergics are a logical alternative for reducing generalized sweating in these patients. Twenty-one patients were medicated with 5 or 10 mg of oxybutynin per day. After a 3-month follow-up period, efficacy was assessed with the Hyperhidrosis Disease Severity Scale (HDSS) and the Dermatology Life Quality Index (DLQI) was used to assess the improvement in patients' quality of life. The HDSS score was 3.2 +/- 0.4 (mean +/- SD) before medication and 1.9 +/- 0.4 after 3 months. The baseline DLQI score of 8.4 +/- 1.0 was reduced to 4.4 +/- 0.9. No serious side-effects or adverse events resulted from treatment. Oxybutynin was a well-tolerated, effective, and safe method for treating postmenopausal sweating. However, long-term medication and the limited effects of the treatment were disadvantages
Files in This Item:
T201001151.pdf Download
DOI
10.2340/00015555-0828
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kil, Hae Keum(길혜금)
Kim, Won Oak(김원옥)
Yoon, Kyoung Bong(윤경봉) ORCID logo https://orcid.org/0000-0002-4167-1375
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101002
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