3 233

Cited 31 times in

Serum calprotectin as a marker for disease activity and severity in adult-onset Still's disease

Authors
 SANG-YOUN JUNG  ;  YONG-BEOM PARK  ;  YOU-JUNG HA  ;  KWANG-HOON LEE  ;  SOO-KON LEE 
Citation
 JOURNAL OF RHEUMATOLOGY, Vol.37(5) : 1029-1034, 2010 
Journal Title
 JOURNAL OF RHEUMATOLOGY 
ISSN
 0315-162X 
Issue Date
2010
MeSH
Adult ; Biomarkers/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Health Status ; Humans ; Leukocyte L1 Antigen Complex/blood* ; Male ; Middle Aged ; Severity of Illness Index* ; Statistics, Nonparametric ; Still's Disease, Adult-Onset/blood* ; Still's Disease, Adult-Onset/physiopathology
Keywords
CALPROTECTIN ; ADULT ONSET STILL’S DISEASE DISEASE ; ACTIVITY MARKER
Abstract
OBJECTIVE: Calprotectin is a calcium-binding cytosolic protein of the neutrophil, monocyte, and macrophage, and its secretion increases during activation of these cells. Our objective was to measure serum calprotectin concentrations in patients with adult-onset Still's disease (AOSD) and to correlate serum calprotectin with the activity and severity of AOSD. METHODS: We enrolled 25 patients with AOSD and 30 age- and sex-matched healthy controls. Thirty-one serum samples were obtained from patients with AOSD during active or inactive disease and were assayed for calprotectin by ELISA. Clinical and laboratory data related to disease activity and severity were collected at the same time, and systemic scores for disease severity were calculated. RESULTS: Mean calprotectin levels in patients with AOSD were significantly higher than in controls (57.11 +/- 25.38 ng/ml vs 34.90 +/- 4.85 ng/ml, respectively; p < 0.05). Patients with active AOSD had a significantly higher mean calprotectin level than those with inactive disease (61.26 +/- 25.59 ng/ml vs 35.32 +/- 5.90 ng/ml; p < 0.05). Calprotectin levels decreased significantly after treatment in all 6 patients with AOSD from whom followup samples were obtained (p = 0.028). Serum calprotectin showed strong correlations with serum ferritin (r = 0.686, p < 0.001), lactate dehydrogenase (r = 0.647, p < 0.001), leukocyte count (r = 0.774, p < 0.001), aspartate aminotransferase (r = 0.387, p = 0.042), and C-reactive protein (r = 0.588, p = 0.001), but not with erythrocyte sedimentation rate, arginine aminotransferase, hemoglobin, or platelet count. Serum calprotectin showed a significant correlation with AOSD systemic scores, reflecting disease severity (r = 0.803, p < 0.001). CONCLUSION: Serum calprotectin increased in patients with AOSD, in close correlation with disease activity and severity. These findings suggest that serum calprotectin can provide a reliable clinical marker for monitoring the disease activity and severity of AOSD.
Full Text
http://jrheum.org/content/37/5/1029.abstract
DOI
10.3899/jrheum.091120
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Lee, Kwang Hoon(이광훈)
Lee, Soo Kon(이수곤)
Jung, Sang Youn(정상윤)
Ha, You Jung(하유정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100988
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse