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Neointimal coverage on drug-eluting stent struts crossing side-branch vessels using optical coherence tomography

Authors
 Ae-Young Her  ;  Byoung Kwon Lee  ;  Jae-Min Shim  ;  Jung-Sun Kim  ;  Byoung-Keuk Kim  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Myeong-Ki Hong 
Citation
 AMERICAN JOURNAL OF CARDIOLOGY, Vol.105(11) : 1565-1569, 2010 
Journal Title
 AMERICAN JOURNAL OF CARDIOLOGY 
ISSN
 0002-9149 
Issue Date
2010
MeSH
Aged ; Angioplasty, Balloon, Coronary* ; Coronary Artery Disease/diagnosis* ; Coronary Artery Disease/pathology ; Coronary Artery Disease/therapy ; Coronary Restenosis/pathology ; Coronary Restenosis/prevention & control* ; Coronary Vessels/pathology* ; Drug Therapy, Combination ; Drug-Eluting Stents* ; Female ; Follow-Up Studies ; Humans ; Immunosuppressive Agents/administration & dosage ; Male ; Middle Aged ; Platelet Aggregation Inhibitors/administration & dosage ; Retrospective Studies ; Tomography, Optical Coherence/methods* ; Treatment Outcome ; Tunica Intima/pathology*
Abstract
The status of neointimal coverage on the drug-eluting stent (DES) struts, which are placed across the side-branch vessels, remains unclear. The degree of neointimal coverage of stent struts crossing the side-branch vessel was evaluated according to the different types of DESs. Follow-up optical coherence tomography images at 9.3 months after the index procedure were identified in 51 patients who had undergone DES (sirolimus-eluting stents [SESs] in 22 patients, paclitaxel-eluting stents [PESs] in 15, and zotarolimus-eluting stents [ZESs] in 14) implantation with crossover of the side-branch vessels (size >2.0 mm). The enrolled patients were classified as a covered group if every unapposed strut showed neointimal coverage or an uncovered group if any struts lacked neointimal coverage. The neointimal hyperplasia thickness was also measured. The number of patients in the covered group was 15 (29%), with 36 patients in the uncovered group. Significant differences were found in the proportion of the covered group among the 3 DES types (6 [27%] of 22 with SESs, 1 [7%] of 15 with PESs, and 8 [57%] of 14 with ZESs; p = 0.011). The percentage of neointimal coverage in the overall stent struts was also significantly different among the 3 DES types (65% of 356 struts, 20% of 165 struts, and 83% of 143 struts for the SESs, PESs, and ZESs, respectively; p<0.001). The neointimal hyperplasia thickness in the PES group was significantly smaller than those of the ZES and SES groups (0.02 +/- 0.02 mm vs 0.08 +/- 0.06 mm and 0.04 +/- 0.03 mm, respectively; p = 0.002). In conclusion, different patterns of neointimal coverage of the stent struts crossing the side branch vessels were observed according to the type of DES.
Full Text
http://www.sciencedirect.com/science/article/pii/S0002914910000998
DOI
10.1016/j.amjcard.2010.01.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shim, Jae Min(심재민)
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Her, Ae Young(허애영)
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100981
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