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Effect of vessel size on lipid content of coronary plaques assessed by integrated backscatter intravascular ultrasound.

 Young-Guk Ko  ;  Jung-Woo Son  ;  Sang Min Park  ;  Jung-Sun Kim  ;  Donghoon Choi  ;  Myeong-Ki Hong  ;  Yangsoo Jang 
 CIRCULATION JOURNAL, Vol.74(4) : 754-759, 2010 
Journal Title
Issue Date
Acute Coronary Syndrome/metabolism* ; Acute Coronary Syndrome/therapy ; Aged ; Angioplasty, Balloon, Coronary ; Coronary Artery Disease/metabolism* ; Coronary Artery Disease/therapy ; Coronary Vessels/diagnostic imaging* ; Coronary Vessels/metabolism* ; Female ; Humans ; Lipid Metabolism/physiology* ; Male ; Middle Aged ; Regression Analysis ; Retrospective Studies ; Ultrasonography, Interventional/methods*
Acute coronary syndrome ; Intravascular ultrasound ; Lipids ; Plaque
BACKGROUND: Tissue characterization of coronary plaques is feasible using integrated backscatter intravascular ultrasound (IB-IVUS), and higher lipid content has been found in the target lesions of acute coronary syndrome (ACS). The present study was performed to identify clinical and IVUS parameters that correlate with plaque composition assessed by IB-IVUS. METHODS AND RESULTS: A total of 109 patients (age 60.0+/-9.7 years) were evaluated with IVUS and IB-IVUS prior to percutaneous coronary intervention. Patients with ACS had a larger vessel size and higher plaque burden in the target lesion than those with stable angina. Relative lipid content of the target lesion by IB-IVUS was also higher in ACS (43.6%+/-12.0% vs 29.9%+/-14.2%; P<0.001). The remodeling index (r=0.403, P<0.001), plaque burden (%) (r=0.495, P<0.001), and vessel size (r=0.572, P<0.001) significantly correlated with lipid content. In the multiple regression analysis, vessel size was the most important independent predictor of lipid content followed by presence of ACS and the remodeling index. CONCLUSIONS: ACS, positive remodeling, and larger plaque burden were associated with higher lipid content of coronary plaque. However, the lipid content on IB-IVUS was also significantly affected by vessel size. Therefore, qualitative, morphologic assessment of coronary plaque rather than simple quantitative analysis of tissue components seems to be more appropriate for the identification of vulnerable plaque using IB-IVUS.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Park, Sang Min(박상민)
Son, Jung Woo(손정우)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
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