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Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords

Authors
 정효일  ;  박태선  ;  이배환  ;  윤성현  ;  이우영  ;  김왕배 
Citation
 NEUROSCIENCE RESEARCH, Vol.67(1) : 59-64, 2010 
Journal Title
NEUROSCIENCE RESEARCH
ISSN
 0168-0102 
Issue Date
2010
MeSH
Animals ; Anti-Arrhythmia Agents/pharmacology* ; Demyelinating Diseases/chemically induced ; Demyelinating Diseases/physiopathology* ; Ethidium ; Evoked Potentials, Motor/drug effects* ; Male ; Mexiletine/pharmacology* ; Neuroprotective Agents/pharmacology* ; Rats ; Rats, Sprague-Dawley ; Sodium Channel Blockers/pharmacology* ; Spinal Cord/drug effects* ; Spinal Cord/physiopathology ; Spinal Cord Diseases/chemically induced ; Spinal Cord Diseases/physiopathology*
Keywords
Mexiletine ; Motor evoked potentials ; Gliotoxin ; Demyelination ; Spinal cord ; Rat
Abstract
This study was conducted to whether the administration of mexiletine, a Na+ channel blocker, impacts the recovery from demyelination. Under anesthesia, 0.1% ethidium bromide was injected into the dorsal funiculus (T3), followed by a mexiletine or saline treatment. Motor evoked potential (MEP) recordings and luxol fast blue stainings were performed at one, seven, 14, and 21 days post-operatively. Conduction was delayed during demyelination, but the mexiletine-injected group demonstrated shortened latencies and reductions in the demyelination area when compared to the control. These results suggest that systemic mexiletine plays a positive role in protecting neural tissues from demyelination.
Full Text
http://www.sciencedirect.com/science/article/pii/S0168010210000350
DOI
10.1016/j.neures.2010.01.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Do Heum(윤도흠) ORCID logo https://orcid.org/0000-0003-1452-5724
Lee, Kyung Hee(이경희)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100892
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