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Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease

DC FieldValueLanguage
dc.contributor.author강윤-
dc.contributor.author김승원-
dc.contributor.author김원호-
dc.contributor.author김은수-
dc.contributor.author김태일-
dc.contributor.author문창모-
dc.contributor.author박재준-
dc.contributor.author천재희-
dc.contributor.author홍성필-
dc.date.accessioned2015-04-23T16:36:16Z-
dc.date.available2015-04-23T16:36:16Z-
dc.date.issued2010-
dc.identifier.issn0024-3205-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100885-
dc.description.abstractAIMS: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of many immune-mediated diseases. We investigated the relationship between STAT4 single nucleotide polymorphisms (SNPs) and susceptibility to ulcerative colitis (UC) and Crohn's disease (CD) and disease phenotypes in the Korean population. MAIN METHODS: We performed a case-control association study in individuals with UC (N=246), CD (N=182), and healthy controls (N=229). KEY FINDINGS: We genotyped 8 STAT4 SNPs (rs11889341, rs7574865, rs8179673, rs6752770, rs925847, rs10168266, rs10181656, and rs11685878) in the STAT4 gene in patients and controls. SNP rs925847 in the STAT4 gene was significantly associated with susceptibility to UC (P=0.025; OR=0.63) in dominant genotype analysis, though none of these SNPs were associated with CD susceptibility. Moreover, a significant association was identified between SNP rs11889341 and joint involvement (P=0.040; OR=3.79), and between SNP rs925847 and eye involvement (P=0.030; OR=2.42) in UC patients. For CD, rs925847 genetic variant was associated with joint (P=0.029; OR=3.93) and perianal lesions (P=0.033; OR=2.27). SIGNIFICANCE: Our data demonstrated that the STAT4 genetic variants could predispose an individual to IBD and its extra-intestinal ailments in Koreans, suggesting the common pathogenesis of IBD (especially, extra-intestinal manifestations) and other autoimmune diseases-
dc.description.statementOfResponsibilityopen-
dc.format.extent661~667-
dc.relation.isPartOfLife Sciences-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAssociation of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorChang Mo Moon-
dc.contributor.googleauthorJae Hee Cheon-
dc.contributor.googleauthorSeung Won Kim-
dc.contributor.googleauthorDong-Jik Shin-
dc.contributor.googleauthorEun Soo Kim-
dc.contributor.googleauthorEun-Soon Shin-
dc.contributor.googleauthorYoon Kang-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorSung Pil Hong-
dc.contributor.googleauthorSu Youn Nam-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.identifier.doi10.1016/j.lfs.2010.02.016-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00065-
dc.contributor.localIdA00774-
dc.contributor.localIdA01079-
dc.contributor.localIdA01390-
dc.contributor.localIdA01636-
dc.contributor.localIdA04404-
dc.contributor.localIdA04030-
dc.contributor.localIdA00804-
dc.contributor.localIdA00656-
dc.relation.journalcodeJ02167-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0024320510000779-
dc.contributor.alternativeNameKang, Yoon-
dc.contributor.alternativeNameKim, Seung Won-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Eun Soo-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNameMoon, Chang Mo-
dc.contributor.alternativeNamePark, Jae Jun-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameHong, Sung Pil-
dc.contributor.affiliatedAuthorKang, Yoon-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorMoon, Chang Mo-
dc.contributor.affiliatedAuthorPark, Jae Jun-
dc.contributor.affiliatedAuthorHong, Sung Pil-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.contributor.affiliatedAuthorKim, Eun Soo-
dc.contributor.affiliatedAuthorKim, Seung Won-
dc.citation.volume86-
dc.citation.number17-18-
dc.citation.startPage661-
dc.citation.endPage667-
dc.identifier.bibliographicCitationLife Sciences, Vol.86(17-18) : 661-667, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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