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A comparative analysis of cognitive profiles and white-matter alterations using voxel-based diffusion tensor imaging between patients with Parkinson's disease dementia and dementia with Lewy bodies

Authors
 Ji E Lee  ;  Hae-Jeong Park  ;  BoSuk Park  ;  Sook K Song  ;  Young H Sohn  ;  Jong Doo Lee  ;  Phil Hyu Lee 
Citation
 JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol.81(3) : 320-326, 2010 
Journal Title
 JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 
ISSN
 0022-3050 
Issue Date
2010
MeSH
Aged ; Aged, 80 and over ; Cerebral Cortex/pathology* ; Dementia/diagnosis* ; Diagnosis, Differential ; Diffusion Tensor Imaging* ; Dominance, Cerebral/physiology ; Female ; Gyrus Cinguli/pathology* ; Humans ; Lewy Body Disease/diagnosis* ; Male ; Middle Aged ; Nerve Fibers, Myelinated/pathology ; Neuropsychological Tests* ; Parkinson Disease/diagnosis*
Abstract
BACKGROUND: Despite clinical and neuropsychological similarities between Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), recent studies have demonstrated that structural and pathological changes are more severe in DLB than in PDD. METHODS: 19 patients with probable PDD and 18 patients with probable DLB who had a similar overall severity of dementia and demographic characteristics were examined by a standardised neuropsychological test and voxel-based analysis of fractional anisotropy (FA) using diffusion tensor imaging (DTI). RESULTS: The patients with DLB performed significantly worse in visual recognition memory, semantic fluency and ideomotor praxis than those with PDD (p<0.05). Compared with controls, the FA value in patients with PDD was significantly lower in bilateral frontal, left temporal and left parietal white matter. In patients with DLB, the pattern of FA reduction was similar to that of patients with PDD; however, white-matter abnormalities were more severe and extended into bilateral insular, bilateral posterior cingular and bilateral visual association regions. In a direct comparison between PDD and DLB, the FA value in patients with DLB was significantly decreased in bilateral posterior temporal, posterior cingular and bilateral visual association fibres extending into occipital areas. CONCLUSIONS: Despite global similarities in cognitive performance and white-matter pathology between DLB and PDD patients, those with DLB had more severely impaired frontal and temporal area-associated cognitive subsets, and more severe white-matter pathology in temporal and visual association fibres. These data suggest that differences in the underlying nature of PDD and DLB may exist with global similarities in their cognitive performance and white-matter pathology.
Full Text
http://jnnp.bmj.com/content/81/3/320.long
DOI
10.1136/jnnp.2009.184747
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Song, Sook Keun(송숙근)
Lee, Jong Doo(이종두)
Lee, Ji Eun(이지은)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100793
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