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Automated detection of malaria-associated pseudoeosinophilia and abnormal WBC scattergram by the Sysmex XE-2100 hematology analyzer: a clinical study with 1,801 patients and real-time quantitative PCR analysis in vivax malaria-endemic area

Authors
 Jong-Ha Yoo  ;  Jaewoo Song  ;  Kyung-A Lee  ;  Young-Kyu Sun  ;  Young-Ah Kim  ;  Tae Sung Park  ;  Jong Rak Choi 
Citation
 AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol.82(3) : 412-414, 2010 
Journal Title
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
ISSN
 0002-9637 
Issue Date
2010
MeSH
Automation ; Endemic Diseases ; Eosinophilia/blood ; Eosinophilia/complications ; Eosinophilia/diagnosis ; Hematologic Tests/instrumentation* ; Hematologic Tests/methods ; Humans ; Leukocyte Count/instrumentation* ; Leukocyte Count/methods ; Malaria/complications* ; Malaria, Vivax/blood ; Malaria, Vivax/complications* ; Malaria, Vivax/diagnosis ; Polymerase Chain Reaction/methods* ; Sensitivity and Specificity
Abstract
Recently, the XE-2100 hematology analyzer was investigated in a rather small patient group; pseudoeosinophilia or abnormal white blood cell (WBC) scattergrams reported by this instrument were considered as significantly valuable diagnostic parameters in detecting vivax malaria. This study was conducted not only to assess the usefulness of pseudoeosinophilia or abnormal WBC scattergram in vivax malaria-endemic areas with large patient groups (N = 1,801) but also to investigate the correlation of parasitemia and platelet count with pseudoeosinophilia and abnormal WBC scattergrams. Of the 1,801 analyzed patients, 413 (22.9%) were found to have malaria by Wright-Giemsa stained blood smears. Overall, either pseudoeosinophilia or abnormal WBC scattergram was detected in 191 of 413 malaria patients and 4 of 1,388 patients without malaria (sensitivity = 46.2%, specificity = 99.7%). We suggest that clinical hematology laboratories using the XE-2100 analyzer should be aware of such specific parameters, even with the absence of a clinical request.
Files in This Item:
T201000652.pdf Download
DOI
10.4269/ajtmh.2010.09-0560
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100752
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