Cited 44 times in
Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification
DC Field | Value | Language |
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dc.contributor.author | 오의금 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 추상희 | - |
dc.date.accessioned | 2015-04-23T16:26:38Z | - |
dc.date.available | 2015-04-23T16:26:38Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100592 | - |
dc.description.abstract | BACKGROUND: Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a potential insulin sensitizing adipokine, however, the factors determining the levels of circulating vaspin levels have not been fully understood. We investigated the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, and the effects of short-term intensive lifestyle modification on circulating vaspin levels in overweight or obese children. METHODS: A total of 50 (25 boys, 25 girls) overweight or obese children aged 11 to 13 years (average age: 12.0+/-0.9 y, BMI: 25.35+/-86 kg/m(2)) who complied with inclusion criteria participated in our study. To determine the association between adiposity, insulin resistance, lipid profiles and inflammatory markers including vaspin levels, cross-sectional analyses were performed. Thereafter, subjects underwent a tightly controlled seven-day intensive lifestyle modification including physical activity, dietary modification, and behavioral modification education in residence of a local university dormitory. RESULTS: There was a negative correlation between vaspin concentration and fasting insulin (r=-.325, p<0.05) and homeostasis model assessment of insulin resistance (HOMA-IR) (r=-.331, p<0.05) when percent body fat was controlled. Multivariate linear regression analysis found serum vaspin level to be an independent predictor of insulin and HOMA-IR. Short-term intensive lifestyle modification significantly decreased vaspin levels by 39.28% (pre: .84+/-1.0, post: .51+/-1.0 ng/ml, p<0.001) while adiponectin levels increased by 11.2% (pre: 6.50+/-2.89, post: 7.28+/-2.98 ng/ml, p<0.01). In addition, short-term lifestyle modification significantly improved HOMA-IR (pre: 3.58+/-1.93, post 1.30+/-1.9, p<0.001) and lipid profiles. CONCLUSIONS: Serum vaspin level is one of the predictors for insulin resistance and was significantly reduced following short-term lifestyle modification. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 381~385 | - |
dc.relation.isPartOf | CLINICA CHIMICA ACTA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Life Style* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Obesity/blood* | - |
dc.subject.MESH | Serpins/blood* | - |
dc.subject.MESH | Time Factors | - |
dc.title | Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification | - |
dc.type | Article | - |
dc.contributor.college | College of Nursing (간호대학) | - |
dc.contributor.department | Dept. of Nursing Environment Systems (임상간호과학과) | - |
dc.contributor.googleauthor | Mi Kyung Lee | - |
dc.contributor.googleauthor | Yoonsuk Jekal | - |
dc.contributor.googleauthor | Jee-Aee Im | - |
dc.contributor.googleauthor | Eunsung Kim | - |
dc.contributor.googleauthor | Seung Hwan Lee | - |
dc.contributor.googleauthor | Ji-Hye Park | - |
dc.contributor.googleauthor | Sang Hui Chu | - |
dc.contributor.googleauthor | Kyong-Mee Chung | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | Eui Geum Oh | - |
dc.contributor.googleauthor | Sang Hwan Kim | - |
dc.contributor.googleauthor | Justin Y. Jeon | - |
dc.identifier.doi | 10.1016/j.cca.2009.12.003 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02393 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A04232 | - |
dc.relation.journalcode | J00543 | - |
dc.identifier.eissn | 1873-3492 | - |
dc.identifier.pmid | 20018186 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009898109006263 | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | Exercise | - |
dc.subject.keyword | Insulin resistance | - |
dc.subject.keyword | Vaspin | - |
dc.subject.keyword | Adiponectin | - |
dc.contributor.alternativeName | Oh, Eui Geum | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Choo, Sang Hee | - |
dc.contributor.affiliatedAuthor | Oh, Eui Geum | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Choo, Sang Hee | - |
dc.citation.volume | 411 | - |
dc.citation.number | 5-6 | - |
dc.citation.startPage | 381 | - |
dc.citation.endPage | 385 | - |
dc.identifier.bibliographicCitation | CLINICA CHIMICA ACTA, Vol.411(5-6) : 381-385, 2010 | - |
dc.identifier.rimsid | 36586 | - |
dc.type.rims | ART | - |
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