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Inhibitory effect of evodiamine alone and in combination with rosiglitazone on in vitro adipocyte differentiation and in vivo obesity related to diabetes

DC Field Value Language
dc.contributor.author김진문-
dc.contributor.author박홍규-
dc.contributor.author유윤정-
dc.contributor.author차정헌-
dc.date.accessioned2015-04-23T16:26:15Z-
dc.date.available2015-04-23T16:26:15Z-
dc.date.issued2010-
dc.identifier.issn0307-0565-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100580-
dc.description.abstractOBJECTIVE: Evodiamine (evo) has been shown to exert anti-inflammatory, antinociceptive and anticancer effects. In this study, we investigated the effects of evo alone and in combination with rosiglitazone (rosi) on in vitro adipocyte differentiation and in vivo obesity related to diabetes. METHODS: Adipocyte differentiation was investigated in vitro using 3T3-L1 and C3H10T1/2 cells. To determine the degree of differentiation, Oil Red O staining and reverse transcription-PCR were carried out. Four groups of db/db mice were treated intraperitoneally once per day with vehicle, evo, rosi and evo+rosi. The mice were killed after 14 days and the blood, liver and adipose tissue were analyzed. RESULTS: The presence of evo or evo combined with rosi during adipogenic induction has been shown to inhibit adipocyte differentiation to a significant degree, particularly at the commitment and early induction stages. The evo and evo+rosi groups of db/db mice evidenced significant reductions in body weight gain. The ratio of epididymal white adipocyte tissue weight to body weight of the evo group was also significantly reduced. It is important to note that in the evo+rosi treatment, blood glucose levels were reduced to a degree similar to that of the rosi group, and plasma insulin levels were reduced significantly better than that of rosi group. Furthermore, hepatic lesions associated with fat and glycogen deposition were morphologically improved in the evo and evo+rosi groups. CONCLUSION: The results of this study showed that evo exerts an inhibitory effect on in vitro adipocyte differentiation and in vivo obesity, and also an improvement effect on insulin resistance. These desirable effects of evo were noted even in the presence of rosi. These results indicate that evo improves the undesirable effects of rosi, including adipogenesis, body weight gain and hepatotoxicity, while preserving its desirable blood-glucose-lowering effect.-
dc.description.statementOfResponsibilityopen-
dc.format.extent250~260-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF OBESITY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdipocytes/drug effects*-
dc.subject.MESHAdipocytes/metabolism-
dc.subject.MESHAdiponectin-
dc.subject.MESHAdipose Tissue/drug effects-
dc.subject.MESHAdipose Tissue/metabolism*-
dc.subject.MESHAnimals-
dc.subject.MESHBlood Glucose/drug effects-
dc.subject.MESHCell Differentiation/drug effects-
dc.subject.MESHCell Line-
dc.subject.MESHDietary Fats-
dc.subject.MESHDrug Therapy, Combination-
dc.subject.MESHHypoglycemic Agents/administration & dosage-
dc.subject.MESHHypoglycemic Agents/pharmacology*-
dc.subject.MESHInsulin/blood-
dc.subject.MESHLiver/drug effects-
dc.subject.MESHLiver/metabolism-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHObesity/drug therapy-
dc.subject.MESHObesity/metabolism*-
dc.subject.MESHPlant Extracts/administration & dosage-
dc.subject.MESHPlant Extracts/pharmacology*-
dc.subject.MESHQuinazolines/administration & dosage-
dc.subject.MESHQuinazolines/pharmacology*-
dc.subject.MESHThiazolidinediones/administration & dosage-
dc.subject.MESHThiazolidinediones/pharmacology*-
dc.subject.MESHWeight Gain/drug effects-
dc.titleInhibitory effect of evodiamine alone and in combination with rosiglitazone on in vitro adipocyte differentiation and in vivo obesity related to diabetes-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorE J Bak-
dc.contributor.googleauthorH G Park-
dc.contributor.googleauthorJ M Kim-
dc.contributor.googleauthorJ M Kim-
dc.contributor.googleauthorY-J Yoo-
dc.contributor.googleauthorJ-H Cha-
dc.identifier.doi10.1038/ijo.2009.223-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01014-
dc.contributor.localIdA01771-
dc.contributor.localIdA02490-
dc.contributor.localIdA04007-
dc.relation.journalcodeJ01140-
dc.identifier.eissn1476-5497-
dc.identifier.pmid19859078-
dc.identifier.urlhttp://www.nature.com/ijo/journal/v34/n2/full/ijo2009223a.html-
dc.contributor.alternativeNameKim, Jin Moon-
dc.contributor.alternativeNamePark, Hong Gyu-
dc.contributor.alternativeNameYoo, Yun Jung-
dc.contributor.alternativeNameCha, Jung Heon-
dc.contributor.affiliatedAuthorKim, Jin Moon-
dc.contributor.affiliatedAuthorPark, Hong Gyu-
dc.contributor.affiliatedAuthorYoo, Yun Jung-
dc.contributor.affiliatedAuthorCha, Jung Heon-
dc.citation.volume34-
dc.citation.number2-
dc.citation.startPage250-
dc.citation.endPage260-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF OBESITY, Vol.34(2) : 250-260, 2010-
dc.identifier.rimsid36578-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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