0 308

Cited 40 times in

Serum leptin is associated with metabolic syndrome in obese and nonobese Korean populations

Authors
 Ji Eun Yun  ;  Heejin Kimm  ;  Jaeseong Jo  ;  Sun Ha Jee 
Citation
 METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.59(3) : 424-429, 2010 
Journal Title
METABOLISM-CLINICAL AND EXPERIMENTAL
ISSN
 0026-0495 
Issue Date
2010
MeSH
Abdominal Fat/physiology ; Adult ; Body Mass Index ; Female ; Humans ; Hyperglycemia/blood ; Hyperglycemia/complications ; Hypertension/blood ; Hypertension/epidemiology ; Leptin/blood* ; Lipids/blood ; Male ; Metabolic Syndrome/blood* ; Metabolic Syndrome/epidemiology* ; Middle Aged ; Obesity/blood* ; Obesity/epidemiology* ; Odds Ratio ; Republic of Korea/epidemiology ; Triglycerides/blood ; Waist Circumference
Abstract
Leptin is mainly secreted from adipose tissue and is known to be associated with cardiovascular diseases. However, there are not many studies on the association between serum leptin and metabolic syndrome. The objective of this study was to determine the association between serum leptin and metabolic syndrome among the Korean adult population. The study population consisted of 3,272 Koreans (men: 1,915, women: 1,357) 30 to 84 years of age who had visited the Health Examination Center. Leptin levels were divided into quintiles and metabolic syndrome was defined by NCEP ATP III. The serum leptin levels increased as the number of components present for metabolic syndrome increased. Controlling for age, smoking, exercise, and LDL cholesterol, subjects with high leptin levels were more likely to have an elevated risk of metabolic syndrome than those with lower levels in both men and women. Subjects in the highest leptin quintile were found to have a higher risk of having metabolic syndrome than those in the lowest quintile (OR = 11.51 for men; OR = 4.65 for women). After further adjustment of the BMI, the risk of metabolic syndrome still increased slightly for men but not for women in increasing leptin categories. This association of leptin levels and metabolic syndrome did not change after stratification into obese and nonobese weight status. Serum leptin is associated with metabolic syndrome in Korean populations independent of body mass index. Thus, the reduction of circulating leptin may confer cardiovascular and metabolic protective effects regardless of weight status
Full Text
http://www.sciencedirect.com/science/article/pii/S002604950900345X
DOI
10.1016/j.metabol.2009.08.012
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kimm, Heejin(김희진) ORCID logo https://orcid.org/0000-0003-4526-0570
Yun, Ji Eun(윤지은)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100560
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links