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A comparison of gray and white matter density in patients with Parkinson's disease dementia and dementia with Lewy bodies using voxel-based morphometry

Authors
 Ji E. Lee  ;  Bosuk Park  ;  Sook K. Song  ;  Young H. Sohn  ;  Hae-Jeong Park  ;  Phil Hyu Lee 
Citation
 MOVEMENT DISORDERS, Vol.25(1) : 28-34, 2010 
Journal Title
MOVEMENT DISORDERS
ISSN
 0885-3185 
Issue Date
2010
MeSH
Aged ; Aged, 80 and over ; Brain/pathology* ; Female ; Humans ; Imaging, Three-Dimensional/methods ; Lewy Body Disease/pathology* ; Magnetic Resonance Imaging/methods ; Male ; Parkinson Disease/pathology* ; Severity of Illness Index
Keywords
dementia with Lewy bodies ; gray matter density ; Parkinson's disease dementia ; voxel‐based morphometry ; white matter density
Abstract
Despite clinical and neuropsychological similarities between Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), recent studies have demonstrated that structural and pathological changes are more severe in DLB than in PDD. We used voxel-based morphometry using a 3-T MRI scanner to compare gray and white matter densities in 20 patients with probable PDD and 18 patients with probable DLB, who had similar overall severity of dementia and similar demographic characteristics. The gray matter density was significantly decreased in the left occipital, parietal, and striatal areas in patients with DLB compared with patients with PDD. The white matter density was significantly decreased in bilateral occipital and left occipito-parietal areas in patients with DLB compared with those with PDD. The degree of white and gray matter atrophy was similar in patients with DLB; in contrast, there was markedly less atrophy in the white matter than in the gray matter in patients with PDD. On analyzing the change of WM density relative to that of GM density in patients with DLB compared to those with PDD, the area of WM atrophy in the occipital areas was more extensive than that of GM atrophy. Our data demonstrate that atrophy of both gray and white matter was more severe in patients with DLB and that white matter atrophy relative to gray matter atrophy was less severe in patients with PDD. These data may reflect a difference in the underlying nature of PDD and DLB
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mds.22858/abstract
DOI
10.1002/mds.22858
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100558
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