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What are 'true normal' liver stiffness values using FibroScan?: a prospective study in healthy living liver and kidney donors in South Korea

Authors
 Seung Up Kim  ;  Gi Hong Choi  ;  Woong Kyu Han  ;  Beom Kyung Kim  ;  Jun Yong Park  ;  Do Young Kim  ;  Jin Sub Choi  ;  Seung Choul Yang  ;  Eun Hee Choi  ;  Sang Hoon Ahn  ;  Kwang-Hyub Han  ;  Chae Yoon Chon 
Citation
 LIVER INTERNATIONAL, Vol.30(2) : 268-274, 2010 
Journal Title
 LIVER INTERNATIONAL 
ISSN
 1478-3223 
Issue Date
2010
MeSH
Adult ; Age Factors ; Elasticity Imaging Techniques/methods* ; Female ; Humans ; Liver/anatomy & histology* ; Liver/diagnostic imaging* ; Liver/physiology ; Living Donors ; Male ; Middle Aged ; Prospective Studies ; Reference Values ; Republic of Korea ; Sex Factors ; Tissue Donors* ; Young Adult
Keywords
age ; FibroScan® ; gender ; healthy individual ; liver donor ; liver stiffness measurement ; kidney donor ; transient elastography ; transplantation
Abstract
AIMS: To identify the normal range of liver stiffness (LS) values by recruiting healthy living liver and kidney donors in South Korea. METHODS: Liver stiffness measurement (LSM) was performed in 69 healthy living liver and kidney donors who were admitted for transplantation. None of the subjects suffered from diabetes mellitus, hypertension, hepatitis B virus infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or metabolic syndrome. RESULTS: LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available liver histology, eight showed normal liver histology and four showed liver steatosis of <5% of the hepatocytes. The mean age of our study population was 38.9+/-11.9 years (35 men and 34 women), with a mean LS value of 4.6+/-0.5 kPa (range 3.3-5.6 kPa). LS values were not significantly different between men (4.6+/-0.6 kPa) and women (4.5+/-0.5 kPa, P=0.636), nor were they significantly different according to age (P=0.851). Using the fifth and 95th percentiles, we determined the normal range of LS values to be 3.9-5.3 kPa. CONCLUSIONS: We identified the normal range of LS values and found that LS values were not significantly influenced by age and gender
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2009.02172.x/abstract
DOI
10.1111/j.1478-3231.2009.02172.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Yang, Seung Choul(양승철)
Chon, Chae Yoon(전재윤)
Choi, Gi Hong(최기홍) ORCID logo https://orcid.org/0000-0002-1593-3773
Choi, Eun Hee(최은희)
Choi, Jin Sub(최진섭)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100551
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