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Prevalence and clinical relevance of cyclooxygenase-1 and -2 expression in stage IIB cervical adenocarcinoma

Authors
 Yong Wook Jung  ;  Sang Wun Kim  ;  Sunghoon Kim  ;  Jae Hoon Kim  ;  Nam Hoon Cho  ;  Jae Wook Kim  ;  Young Tae Kim 
Citation
 EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol.148(1) : 62-66, 2010 
Journal Title
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
ISSN
 0301-2115 
Issue Date
2010
MeSH
Adenocarcinoma/genetics* ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Adult ; Aged ; Combined Modality Therapy ; Cyclooxygenase 1/biosynthesis* ; Cyclooxygenase 1/genetics ; Cyclooxygenase 2/biosynthesis* ; Cyclooxygenase 2/genetics ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Prognosis ; Uterine Cervical Neoplasms/genetics* ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/therapy
Keywords
Cyclooxygenase-1 ; Cyclooxygenase-2 ; Cervical cancer ; Adenocarcinoma ; Prognosis
Abstract
OBJECTIVE: The objective of this study was to determine the relationship between cyclooxygenase (COX)-1 and -2 and prognosis in patients diagnosed with FIGO stage IIB cervical adenocarcinoma who underwent concurrent chemoradiotherapy.

STUDY DESIGN: Twenty-three patients diagnosed with stage IIB cervical adenocarcinoma and treated with concurrent chemoradiotherapy between 1990 and 1995 were included in this study. COX-1 and -2 expression and clinicopathologic features were evaluated. COX-1 and -2 expression was determined by immunohistochemistry.

RESULTS: The prevalence of COX-1 and -2 expression was similar at 73.9%. Significant COX-1 and -2 expression was 47.8 and 60.9%, respectively. COX-2 expression was associated with poor response to treatment and cancer-related death (P=0.043 and 0.012, respectively). Poor survival was identified in patients who showed high COX-2 expression (P=0.016). There was no correlation between COX-1 expression and patient prognosis.

CONCLUSION: Only COX-2 was found to be a potent prognostic factor in patients treated with concurrent chemoradiotherapy for stage IIB cervical adenocarcinoma. However, further studies with more samples are needed to definitely demonstrate the relationship between COX expression and cervical adenocarcinoma.
Full Text
http://www.sciencedirect.com/science/article/pii/S0301211509005491
DOI
10.1016/j.ejogrb.2009.09.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Wook(김재욱)
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Jung, Yong Wook(정용욱)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100528
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