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Relationship between multiple plasma biomarkers and vulnerable plaque determined by virtual histology intravascular ultrasound

Authors
 Jong-Pil Park  ;  Byoung Kwon Lee  ;  Jae-Min Shim  ;  Sung-Hwan Kim  ;  Cheol Whan Lee  ;  Duk-Hyun Kang  ;  Myeong-Ki Hong 
Citation
 CIRCULATION JOURNAL, Vol.74(2) : 332-336, 2010 
Journal Title
CIRCULATION JOURNAL
ISSN
 1346-9843 
Issue Date
2010
MeSH
Adiponectin/blood ; Aged ; Biomarkers/blood ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnosis* ; Coronary Artery Disease/diagnostic imaging ; Female ; Humans ; Intramolecular Oxidoreductases/blood ; Logistic Models ; Macrophage Migration-Inhibitory Factors/blood ; Male ; Matrix Metalloproteinase 2/blood ; Matrix Metalloproteinase 9/blood* ; Middle Aged ; Necrosis ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Rupture ; Tissue Inhibitor of Metalloproteinase-1/blood ; Ultrasonography, Interventional* ; Up-Regulation
Keywords
Coronary disease ; Plaque ; Ultrasonics
Abstract
BACKGROUND: The relationship between plasma biomarkers and vulnerable plaque is not well understood.

METHODS AND RESULTS: The 188 patients who underwent 3-vessel virtual histology (VH) intravascular ultrasound (IVUS) with peripheral blood sampling were enrolled. Plasma levels of matrix metalloproteinase 2 and 9 (MMP-2, -9), tissue inhibitor of metalloproteinase-1, adiponectin, and macrophage migration inhibitory factor were measured. VH-IVUS-derived thin cap fibroatheroma (VH-TCFA) was defined as a necrotic core >10% of plaque area in the presence of >40% plaque burden. There were 38 patients with ruptured plaque and 150 patients without (107 patients with VH-TCFA, 43 patients without VH-TCFA) in culprit/target lesions. Among the biomarkers, only the MMP-9 level was significantly higher in patients with ruptured plaque (P=0.002). In the subgroup without ruptured plaque, significant differences in the levels of several biomarkers were not observed between patients with and without VH-TCFA. In both culprit/target and nonculprit/non-target vessels, the MMP-9 level showed a weak correlation with the total number of ruptured plaques (r=0.231, P=0.002).

CONCLUSIONS: Among the biomarkers tested in this study, the MMP-9 level was significantly higher in patients with ruptured plaque. However, measurement of several biomarkers, including MMP-9, was incapable of predicting the presence of VH-TCFA
Files in This Item:
T201000144.pdf Download
DOI
10.1253/circj.CJ-09-0570
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Shim, Jae Min(심재민)
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100518
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