Cited 10 times in
In vitro osteoblast differentiation is negatively regulated by Hoxc8
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정현주 | - |
dc.contributor.author | 김명희 | - |
dc.contributor.author | 민혜현 | - |
dc.contributor.author | 강명모 | - |
dc.date.accessioned | 2015-04-23T16:24:04Z | - |
dc.date.available | 2015-04-23T16:24:04Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0273-2289 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100514 | - |
dc.description.abstract | Hoxc8 has multiple roles in normal skeletal development. In this paper, a MC3T3-E1 subclone 4 osteogenic cell differentiation model was used to examine expression of Hoxc8 at multiple stages of osteogenesis. We found that Hoxc8 expression levels do not change in the early stage but increase in the middle stage and decrease in the late stage of osteogenesis. A knockdown of Hoxc8 by small-interfering RNA transfection in C2C12 cells indicated that Hoxc8 is a negative regulator of osteogenesis. Similarly, expression of Hoxc8 in C2C12 cells decreases alkaline phosphatase levels induced by bone morphogenetic protein-2 (BMP-2). The results of this study showed that Hoxc8 is involved in BMP-2-induced osteogenesis, and osteoblast differentiation in vitro is negatively regulated by Hoxc8, suggesting that Hoxc8 regulation is essential for osteoblast differentiation | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 891~900 | - |
dc.relation.isPartOf | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Morphogenetic Proteins/pharmacology | - |
dc.subject.MESH | Cell Differentiation*/drug effects | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Clone Cells | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Gene Knockdown Techniques | - |
dc.subject.MESH | Homeodomain Proteins/genetics | - |
dc.subject.MESH | Homeodomain Proteins/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Osteoblasts/cytology* | - |
dc.subject.MESH | Osteoblasts/drug effects | - |
dc.subject.MESH | Osteogenesis/drug effects | - |
dc.subject.MESH | RNA, Small Interfering/genetics | - |
dc.subject.MESH | Transfection | - |
dc.title | In vitro osteoblast differentiation is negatively regulated by Hoxc8 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학) | - |
dc.contributor.googleauthor | Yan-Jun Zheng | - |
dc.contributor.googleauthor | Hyun Joo Chung | - |
dc.contributor.googleauthor | Hyehyun Min | - |
dc.contributor.googleauthor | Myengmo Kang | - |
dc.contributor.googleauthor | Seong Hwan Kim | - |
dc.contributor.googleauthor | Jogeswar Gadi | - |
dc.contributor.googleauthor | Myoung Hee Kim | - |
dc.identifier.doi | 10.1007/s12010-009-8558-3 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00432 | - |
dc.contributor.localId | A01416 | - |
dc.contributor.localId | A03769 | - |
dc.contributor.localId | A04871 | - |
dc.relation.journalcode | J00198 | - |
dc.identifier.eissn | 1559-0291 | - |
dc.identifier.pmid | 19214787 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs12010-009-8558-3 | - |
dc.subject.keyword | Hoxc8 | - |
dc.subject.keyword | Osteoblast | - |
dc.subject.keyword | differentiation | - |
dc.subject.keyword | C2C12 | - |
dc.subject.keyword | MC3T3-E1 | - |
dc.subject.keyword | BMP signaling | - |
dc.contributor.alternativeName | Chung, Huyun Joo | - |
dc.contributor.alternativeName | Kim, Myoung Hee | - |
dc.contributor.alternativeName | Min, Hye Hyun | - |
dc.contributor.alternativeName | Kang, Myeng Mo | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Hee | - |
dc.contributor.affiliatedAuthor | Min, Hye Hyun | - |
dc.contributor.affiliatedAuthor | Chung, Huyun Joo | - |
dc.contributor.affiliatedAuthor | Kang, Myengmo | - |
dc.citation.volume | 160 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 891 | - |
dc.citation.endPage | 900 | - |
dc.identifier.bibliographicCitation | APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, Vol.160(3) : 891-900, 2010 | - |
dc.identifier.rimsid | 36538 | - |
dc.type.rims | ART | - |
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