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Endoscopic evaluation of gastric emptying and effect of mosapride citrate on gastric emptying

 In Su Jung  ;  Jie-Hyun Kim  ;  Hwal Youn Lee  ;  Hyojin Park  ;  Sang In Lee 
 YONSEI MEDICAL JOURNAL, Vol.51(1) : 33-38, 2010 
Journal Title
Issue Date
Adult ; Benzamides/pharmacology* ; Endoscopy/methods* ; Female ; Gastric Emptying/drug effects* ; Gastrointestinal Agents/pharmacology* ; Humans ; Male ; Middle Aged ; Morpholines/pharmacology* ; Radiography ; Radionuclide Imaging/methods* ; Stomach/diagnostic imaging ; Young Adult
Gastric emptying ;  endoscopy ;  scintigraphy ;  radiopaque markers ;  mosapride
PURPOSE: Gastric emptying has been evaluated by scintigraphy in spite of its limitations of time consumption, cost, and danger of radioisotope. Endoscopy is a simple technique, however, its validation for gastric emptying and quantification of food has not yet been investigated. The aim of our study was to assess endoscopic gastric emptying compared with scintigraphy and radiopaque markers (ROMs) studies. We also investigated the effect of a single dose of mosapride on gastric emptying. MATERIALS AND METHODS: Fifteen healthy volunteers underwent scintigraphy. Next day, subjects received a standard solid meal with ROMs and underwent endoscopy and simple abdomen X-ray after 3 hrs. After one week, the same procedure was repeated after ingestion of mosapride (5 mg for group 1, n = 8; 10 mg for group 2, n = 7) 15 min before the meal. Quantification of gastric residue by endoscopy was scored from 0 to 3, and the scores were added up. RESULTS: All subjects completed the study without any complication. The gastric emptying rate [T(1/2) (min)] was in normal range (65.6 +/- 12.6 min). Endoscopic gastric emptying was correlated significantly with gastric clearance of ROMs (r = 0.627, p = 0.012). Endoscopic gastric emptying and gastric clearance of ROMs after administration of mosapride showed significant differences in the 10 mg group (p < 0.05). CONCLUSION: Endoscopy can evaluate gastric emptying safely and simply on an outpatient basis. A 10 mg dose of mosapride enhanced gastric emptying, assessed by both endoscopy and ROMs
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Sang In(이상인)
Lee, Hwal Youn(이활연)
Jung, In Su(정인수)
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