Cited 48 times in
c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance
DC Field | Value | Language |
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dc.contributor.author | 송재진 | - |
dc.date.accessioned | 2015-04-23T16:21:04Z | - |
dc.date.available | 2015-04-23T16:21:04Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100424 | - |
dc.description.abstract | We previously reported two modes of development of acquired TRAIL resistance: early phase and late phase [1]. In these studies, we observed that greater Akt activity and the expression of Bcl-xL were related mainly to the late phase of acquired TRAIL resistance. Recently we became aware of a possible mechanism of early phase TRAIL resistance development through internalization and degradation of TRAIL receptors (DR4 and DR5). Our current studies demonstrate that TRAIL receptors rapidly diminish at the membrane as well as the cytoplasm within 4h after TRAIL exposure, but recover completely after one or two days. Our studies also reveal that Cbl, a ubiquitously expressed cytoplasmic adaptor protein, is responsible for the rapid degradation of TRAIL receptors; Cbl binds to them and induces monoubiquitination of these receptors concurrent with their degeneration soon after TRAIL exposure, creating the early phase of acquired TRAIL resistance. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 553~563 | - |
dc.relation.isPartOf | CELLULAR SIGNALLING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amino Acid Substitution | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mutagenesis, Site-Directed | - |
dc.subject.MESH | Proto-Oncogene Proteins c-cbl/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-cbl/metabolism | - |
dc.subject.MESH | Proto-Oncogene Proteins c-cbl/physiology* | - |
dc.subject.MESH | RNA, Small Interfering/metabolism | - |
dc.subject.MESH | Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism* | - |
dc.subject.MESH | TNF-Related Apoptosis-Inducing Ligand/pharmacology* | - |
dc.subject.MESH | Ubiquitination | - |
dc.title | c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute for Cancer Research (암연구소) | - |
dc.contributor.googleauthor | Jae J. Song | - |
dc.contributor.googleauthor | Miroslaw Jerzy Szczepanski# | - |
dc.contributor.googleauthor | So Young Kim | - |
dc.contributor.googleauthor | Joo-Hang Kim | - |
dc.contributor.googleauthor | Jee Young An | - |
dc.contributor.googleauthor | Yong Tae Kwon | - |
dc.contributor.googleauthor | Marco A. Alcala Jr | - |
dc.contributor.googleauthor | David L. Bartlett | - |
dc.contributor.googleauthor | Yong J. Lee | - |
dc.identifier.doi | 10.1016/j.cellsig.2009.11.012 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02056 | - |
dc.relation.journalcode | J00502 | - |
dc.identifier.eissn | 1873-3913 | - |
dc.identifier.pmid | 19932172 | - |
dc.subject.keyword | c-Cbl | - |
dc.subject.keyword | TRAIL | - |
dc.subject.keyword | TRAIL receptors | - |
dc.subject.keyword | TRAIL resistance | - |
dc.contributor.alternativeName | Song, Jae Jin | - |
dc.contributor.affiliatedAuthor | Song, Jae Jin | - |
dc.citation.volume | 22 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 553 | - |
dc.citation.endPage | 563 | - |
dc.identifier.bibliographicCitation | CELLULAR SIGNALLING, Vol.22(3) : 553-563, 2010 | - |
dc.identifier.rimsid | 36479 | - |
dc.type.rims | ART | - |
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