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Tumor MET expression profile predicts the outcome of non-small cell lung cancer patients receiving epidermal growth factor receptor tyrosine kinase inhibitors

Authors
 Hyun Chang  ;  Xianglan Zhang  ;  Byoung Chul Cho  ;  Hee Jin Park  ;  Joo-Hang Kim 
Citation
 THORACIC CANCER, Vol.5(6) : 517-524, 2014 
Journal Title
 THORACIC CANCER 
ISSN
 1759-7706 
Issue Date
2014
Keywords
Epidermal growth factor receptor ; MET ; non-small cell lung cancer ; tyrosine kinase inhibitor
Abstract
Background : This study assesses whether MET expression in tumor tissue is associated with an increased sensitivity to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer (NSCLC) patients. Methods : This retrospective study included 69 NSCLC participants with available tumor tissue and data on treatment response and survival. MET and hepatocyte growth factor expression in tumor tissue were evaluated by immunohistochemistry. Results : Positive tMET expression correlated with a shorter progression-free survival (PFS; P = 0.003) and overall survival (OS; P = 0.05). Positive pY1234/1235 expression was significantly associated with a longer PFS (P = 0.031) and OS (P = 0.012). In multivariable analyses, tMET and pY1234/1235 expression were independent factors for PFS and OS, respectively. (tMET, PFS; P = 0.02, OS; P = 0.0007 and pY1234/1234, PFS; P = 0.01, OS; P = 0.004). Conclusions : This study suggests that total and phosphorylated MET expression in tumor tissue is potentially useful for the selection of NSCLC patients who are likely to benefit from EGFR-TKIs, irrespective of their EGFR status.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/1759-7714.12122/abstract
DOI
10.1111/1759-7714.12122
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
Park, Hee Jin(박희진)
Cho, Byoung Chul(조병철) ORCID logo https://orcid.org/0000-0002-5562-270X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100332
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