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Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells

DC FieldValueLanguage
dc.contributor.author장인익-
dc.date.accessioned2015-01-06T17:36:13Z-
dc.date.available2015-01-06T17:36:13Z-
dc.date.issued2014-
dc.identifier.issn0021-9258-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/100288-
dc.description.abstractHOTAIR is a long non-coding RNA that interacts with the polycomb repressive complex and suppresses its target genes. HOTAIR has also been demonstrated to promote malignancy. MicroRNA-141 (miR-141) has been reported to play a role in the epithelial to mesenchymal transition process, and the expression of miR-141 is inversely correlated with tumorigenicity and invasiveness in several human cancers. We found that HOTAIR expression is inversely correlated to miR-141 expression in renal carcinoma cells. HOTAIR promotes malignancy, including proliferation and invasion, whereas miR-141 suppresses malignancy in human cancer cells. miR-141 binds to HOTAIR in a sequence-specific manner and suppresses HOTAIR expression and functions, including proliferation and invasion. Both HOTAIR and miR-141 were associated with the immunoprecipitated Ago2 (Argonaute2) complex, and the Ago2 complex cleaved HOTAIR in the presence of miR-141. These results demonstrate that HOTAIR is suppressed by miR-141 in an Ago2-dependent manner.-
dc.description.statementOfResponsibilityopen-
dc.format.extent12550~12565-
dc.relation.isPartOfJournal of Biological Chemistry-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHApoptosis/genetics-
dc.subject.MESHArgonaute Proteins/genetics-
dc.subject.MESHArgonaute Proteins/metabolism-
dc.subject.MESHBase Sequence-
dc.subject.MESHBinding Sites/genetics-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCarcinoma, Renal Cell/genetics-
dc.subject.MESHCarcinoma, Renal Cell/metabolism-
dc.subject.MESHCarcinoma, Renal Cell/pathology-
dc.subject.MESHCell Line-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Proliferation*-
dc.subject.MESHGene Expression Regulation, Neoplastic*-
dc.subject.MESHHT29 Cells-
dc.subject.MESHHomeodomain Proteins/genetics-
dc.subject.MESHHomeodomain Proteins/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHKidney Neoplasms/genetics-
dc.subject.MESHKidney Neoplasms/metabolism-
dc.subject.MESHKidney Neoplasms/pathology-
dc.subject.MESHMicroRNAs/genetics*-
dc.subject.MESHMicroRNAs/metabolism-
dc.subject.MESHMutation-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasms/genetics-
dc.subject.MESHNeoplasms/metabolism-
dc.subject.MESHNeoplasms/pathology-
dc.subject.MESHRNA Interference-
dc.subject.MESHRNA, Long Noncoding/genetics*-
dc.subject.MESHRNA, Long Noncoding/metabolism-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHTranscription Factors/genetics-
dc.subject.MESHTranscription Factors/metabolism-
dc.subject.MESHZinc Finger E-box-Binding Homeobox 1-
dc.titleLong Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorTakeshi Chiyomaru-
dc.contributor.googleauthorShinichiro Fukuhara-
dc.contributor.googleauthorSharanjot Saini-
dc.contributor.googleauthorShahana Majid-
dc.contributor.googleauthorGuoren Deng-
dc.contributor.googleauthorVarahram Shahryari-
dc.contributor.googleauthorInik Chang-
dc.contributor.googleauthorYuichiro Tanaka-
dc.contributor.googleauthorHideki Enokida-
dc.contributor.googleauthorMasayuki Nakagawa-
dc.contributor.googleauthorRajvir Dahiya-
dc.contributor.googleauthorSoichiro Yamamura-
dc.identifier.doi10.1074/jbc.M113.488593-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03461-
dc.relation.journalcodeJ01258-
dc.identifier.pmid24616104-
dc.identifier.urlhttp://www.jbc.org/content/289/18/12550.long-
dc.subject.keywordCancer Biology-
dc.subject.keywordCell Growth-
dc.subject.keywordGene Regulation-
dc.subject.keywordGenistein-
dc.subject.keywordHOTAIR-
dc.subject.keywordInvasion-
dc.subject.keywordLong Non-coding RNA-
dc.subject.keywordMicroRNA-
dc.subject.keywordRenal Carcinoma-
dc.subject.keywordmiR-141-
dc.contributor.alternativeNameChang, In Ik-
dc.contributor.affiliatedAuthorChang, In Ik-
dc.rights.accessRightsfree-
dc.citation.volume289-
dc.citation.number18-
dc.citation.startPage12550-
dc.citation.endPage12565-
dc.identifier.bibliographicCitationJournal of Biological Chemistry, Vol.289(18) : 12550-12565, 2014-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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