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Expression of metabolism-related proteins in invasive lobular carcinoma: comparison to invasive ductal carcinoma

Authors
 Yon Hee Kim  ;  Woo Hee Jung  ;  Ja Seung Koo 
Citation
 TUMOR BIOLOGY, Vol.35(10) : 10381-10393, 2014 
Journal Title
 TUMOR BIOLOGY 
ISSN
 1010-4283 
Issue Date
2014
MeSH
Breast Neoplasms/metabolism* ; Carcinoma, Ductal, Breast/metabolism* ; Carcinoma, Lobular/metabolism* ; Female ; Humans ; Immunohistochemistry ; Tissue Array Analysis
Keywords
Breast cancer ; Lobular cancer ; Metabolism
Abstract
The purpose of this study is to investigate the difference in expression of metabolism-related proteins in invasive lobular carcinoma (ILC) compared to those of the invasive ductal carcinoma (IDC). Tissue microarray was manufactured for 114 cases of ILC and 692 cases of IDC. Immunohistochemical stains were performed as follows: glycolysis (Glut-1, hexokinase II, CAIX, MCT4), glutaminolysis (GLS1, GDH, ASCT2), mitochondria (ATP synthase, SDHA, SDHB), and serine/glycine metabolism (PHGDH, PSAT1, PSPH, SHMT1, GLDC) related proteins. Pleomorphic type (n = 12) of ILC revealed higher expression in hexokinase II, SDHB, and GLDC than classic type (n = 102) (p < 0.05). IDC showed a higher expression of glycolysis (Glut-1, CAIX, MCT4), glutaminolysis (GLS1, ASCT2), and serine/glycine metabolism (PSPH, SHMT1, GLDC) related protein than ILC in tumor cells, whereas ILC revealed higher expression in GDH, SDHA, PHGDH, and PSAT1 than IDC in tumor cells (p < 0.05). In addition, IDC demonstrated a higher expression of metabolism-related proteins than ILC in stromal tissue (p < 0.05). In ILC, tumoral GLDC positivity was correlated with higher nuclear grade (p = 0.026) and higher histologic grade (p = 0.026), and tumoral Glut-1 positivity correlated with higher histologic grade (p = 0.026). Additionally, tumoral PSPH positivity showed a significant correlation to ER negativity and PR negativity (p = 0.026). In conclusion, it reveals different expression patterns of metabolism-related proteins between IDC and ILC
Full Text
http://link.springer.com/article/10.1007%2Fs13277-014-2345-7
DOI
10.1007/s13277-014-2345-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Jung, Woo Hee(정우희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100253
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