An Overview of Eosinophilic Esophagitis

Abstract

Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated esophageal disease affecting both children and adults. The condition is characterized by an eosinophilic infil-tration of the esophageal epithelium. Symptoms of esopha-geal dysfunction include dysphagia, food impaction and symptoms mimicking gastroesophageal reflux disease. Endo-scopic examination typically reveals mucosal fragility, ring or corrugated mucosa, longitudinal furrows, whitish plaques or a small caliber esophagus. Histologic findings of >15 eosino-phils per high-power field is the diagnostic hallmark of EoE. An elimination diet, topical corticosteroids or endoscopic di-lation for fibrostenotic disease serve as effective therapeutic option.