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The effect of perinatal anxiety on bronchiolitis is influenced by polymorphisms in ROS-related genes

Authors
 Eun Lee  ;  Hyoung Yoon Chang  ;  Kyung-Sook Lee  ;  Dong In Suh  ;  Ho-Sung Yu  ;  Mi-Jin Kang  ;  In Ae Choi  ;  Jinah Park  ;  Kyung Won Kim  ;  Youn Ho Shin  ;  Kang Mo Ahn  ;  Ja-Young Kwon  ;  Suk-Joo Choi  ;  Kyung-Ju Lee  ;  Hye-Sung Won  ;  Song I Yang  ;  Young-Ho Jung  ;  Hyung Young Kim  ;  Ju-Hee Seo  ;  Ji-Won Kwon  ;  Byoung-Ju Kim  ;  Hyo-Bin Kim  ;  So-Yeon Lee  ;  Eun-Jin Kim  ;  Joo-Shil Lee  ;  Katherine M Keyes  ;  Yee-Jin Shin  ;  Soo-Jong Hong 
Citation
 BMC Pulmonary Medicine, Vol.14(154) : 1-9, 2014 
Journal Title
 BMC Pulmonary Medicine 
ISSN
 1471-2466 
Issue Date
2014
MeSH
Adult ; Anxiety/immunology ; Anxiety/psychology* ; Bronchiolitis/epidemiology* ; Bronchiolitis/etiology ; Female ; Genetic Predisposition to Disease ; Genotype ; Glutathione S-Transferase pi/genetics* ; Glutathione Transferase/genetics* ; Humans ; Immunity, Innate/genetics* ; Infant ; Infant, Newborn ; Lipopolysaccharide Receptors/genetics* ; Male ; Oxidative Stress/immunology ; Peripartum Period/psychology ; Polymorphism, Genetic ; Pregnancy ; Respiratory Tract Infections/epidemiology* ; Respiratory Tract Infections/etiology
Keywords
Anxiety ; Bronchiolitis ; CD14 ; Perinatal ; Glutathione S-transferase ; Polymorphism ; Respiratory tract infection
Abstract
BACKGROUND: Exposure to perinatal anxiety affects disease susceptibility in offspring but studies on the association between perinatal anxiety and gene polymorphisms are lacking. This study aimed to elucidate the interaction between perinatal anxiety and polymorphisms in antioxidant defense and innate immunity genes on the development of respiratory tract infections (RTIs) during early infancy. METHODS: Trait anxiety levels in 440 women were assessed by the State-Trait Anxiety Inventory during late gestation. The occurrence of RTIs, including bronchiolitis, during the first year of life was assessed by parent-reported doctor diagnosis. Polymorphisms in glutathione S-transferase P-1 (GSTP1, rs1695) and CD14 (rs2569190) were genotyped using the TaqMan assay. Copy number variations of GSTT1 were measured by real-time polymerase chain reaction. RESULTS: Exposure to high levels of perinatal anxiety increased the risk of bronchiolitis in the first year of life (adjusted odds ratio [aOR], 1.30; 95% confidence interval [CI]: 1.00-1.80), in particular among children with the AG + GG genotype of GSTP1 or the GSTT1 null genotype (aOR 3.36 and 2.79). In infants with the TC + CC genotype of CD14, high levels of perinatal anxiety were associated with an increased risk of upper RTI, lower RTI, and bronchiolitis (aOR 2.51, 4.60, and 4.31, respectively). CONCLUSIONS: Perinatal maternal anxiety levels affect the occurrence of bronchiolitis in offspring. The effect of perinatal anxiety on the occurrence of bronchiolitis during infancy was influenced by genetic polymorphisms in antioxidant defense and innate immunity genes.
Files in This Item:
T201403748.pdf Download
DOI
10.1186/1471-2466-14-154
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100203
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