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Prenatal maternal depression is associated with low birth weight through shorter gestational age in term infants in Korea

 Hyoung Yoon Chang  ;  Katherine M. Keyes  ;  Kyung-Sook Lee  ;  In Ae Choi  ;  Se Joo Kim  ;  Kyung Won Kim  ;  Youn Ho Shin  ;  Kang Mo Ahn  ;  Soo-Jong Hongi  ;  Yee-Jin Shin 
 EARLY HUMAN DEVELOPMENT, Vol.90(1) : 15-20, 2014 
Journal Title
Issue Date
Adult ; Birth Weight* ; Case-Control Studies ; Cohort Studies ; Depression/physiopathology* ; Female ; Gestational Age* ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Korea ; Pregnancy ; Pregnancy Complications/physiopathology* ; Prospective Studies
Birth weight for gestational age ; Gestational age ; Low birth weight ; Prenatal depression ; Prospective study ; South Korea
BACKGROUND: Maternal prenatal depression is associated with lower offspring birth weight, yet the impact of gestational age on this association remains inadequately understood. AIMS: We aimed to investigate the effect of prenatal depression on low birth weight, gestational age, and weight for gestational age at term. STUDY DESIGN: Prospective cohort study. SUBJECT: Data were collected from 691 women in their third trimester of pregnancy who went on to give birth to a singleton at term without perinatal complications. One hundred and fifty-two women had a Center for Epidemiologic Studies Depression Scale-10 score ≥10 and were classed as prenatally depressed. OUTCOME MEASURES: Low birth weight (<2500g), gestational age at birth, and birth weight percentile for gestational age. RESULTS: Offspring of prenatally depressed women were more likely to be low birth weight (Odds ratio [OR] 2.94, 95% confidence interval [CI] 1.14-7.58) than offspring of prenatally non-depressed women, but the association was attenuated (OR 1.66, 95% CI 0.55-5.02) when adjusted for gestational age. Offspring of prenatally depressed women had lower gestational age in weeks (OR for one week increase in gestational age: 0.66, 95% CI 0.47-0.93) than offspring of prenatally non-depressed women. There was no association between prenatal depression and birth weight percentile for gestational age. CONCLUSIONS: Prenatal depression was not associated with low birth weight at term, but was associated with gestational age, suggesting that association between maternal depression and birth weight may be a reflection of the impact of depression on offspring gestational age.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
Chang, Hyoung Yoon(장형윤)
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