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Role of the tumor microenvironment in the pathogenesis of gastric carcinoma

Authors
 Hye Won Chung  ;  Jong-Baeck Lim 
Citation
 WORLD JOURNAL OF GASTROENTEROLOGY, Vol.20(7) : 1667-1680, 2014 
Journal Title
 WORLD JOURNAL OF GASTROENTEROLOGY 
ISSN
 1007-9327 
Issue Date
2014
MeSH
Carcinoma/microbiology* ; Carcinoma/pathology* ; Chemokines/metabolism ; Clinical Trials as Topic ; Cytokines/metabolism ; Gastric Mucosa/pathology ; Gastritis/pathology ; Helicobacter Infections/pathology ; Helicobacter pylori ; Humans ; Inflammation ; Macrophages/cytology ; Matrix Metalloproteinases/metabolism ; Signal Transduction ; Stomach Neoplasms/microbiology* ; Stomach Neoplasms/pathology* ; Tumor Microenvironment*
Keywords
Cytokine ; Gastric carcinoma ; Helicobacter pylori ; Inflammation ; Tumor microenvironment
Abstract
Gastric carcinoma (GC) is the 4th most prevalent cancer and has the 2nd highest cancer-related mortality rate worldwide. Despite the incidence of GC has decreased over the past few decades, it is still a serious health problem. Chronic inflammatory status of the stomach, caused by the infection of Helicobacter pylori (H. pylori) and through the production of inflammatory mediators within the parenchyma is suspected to play an important role in the initiation and progression of GC. In this review, the correlation between chronic inflammation and H. pylori infection as an important factor for the development of GC will be discussed. Major components, including tumor-associated macrophages, lymphocytes, cancer-associated fibroblasts, angiogenic factors, cytokines, and chemokines of GC microenvironment and their mechanism of action on signaling pathways will also be discussed. Increasing our understanding of how the components of the tumor microenviroment interact with GC cells and the signaling pathways involved could help identify new therapeutic and chemopreventive targets.
Files in This Item:
T201403737.pdf Download
DOI
10.3748/wjg.v20.i7.1667
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lim, Jong Baeck(임종백) ORCID logo https://orcid.org/0000-0003-0419-0422
Chung, Hye Won(정혜원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100191
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