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An age-related decline of CD62L and vaccine response: a role of microRNA 92a?

Authors
 Jae Il Shin  ;  Jagadeesh Bayry 
Citation
 HUMAN VACCINES & IMMUNOTHERAPEUTICS, Vol.10(5) : 1404-1405, 2014 
Journal Title
HUMAN VACCINES & IMMUNOTHERAPEUTICS
ISSN
 2164-5515 
Issue Date
2014
MeSH
Aging/immunology* ; CD4-Positive T-Lymphocytes/immunology* ; CD8-Positive T-Lymphocytes/immunology* ; Female ; Hepatitis B Antibodies/blood* ; Hepatitis B Surface Antigens/immunology* ; Humans ; L-Selectin/physiology* ; Male
Keywords
CD62L ; CD8+ T-lymphocyte ; immunosenescence ; microRNA 92a ; vaccine response
Abstract
Aging process can affect T cell and antibody response to vaccination and an age-related decline in the expression of CD62L on CD8+ T-lymphocyte is one of the important factors that contribute. A recent report demonstrated that percentage of CD3+CD8+CD62L+ cells and CD8+ T-lymphocyte microRNA-92a levels significantly decline with the age and were positively correlated. These results suggested that the age-related attrition of human naïve T cells could be connected to a reduced microRNA-92a in T-lymphocytes and downregulation of the microRNA-92a level might indicate exhaustion of naïve T-cells due to alteration of the immunologic condition with aging. Further studies are necessary to evaluate whether targeting microRNA-92a as microRNA mimics could be one of the therapeutic strategies in improving vaccine response in elderly.
Full Text
http://www.tandfonline.com/doi/abs/10.4161/hv.27665?journalCode=khvi20#.VIpQedKsXTo
DOI
10.4161/hv.27665
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/100136
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