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Serial changes of neointimal tissue after everolimus-eluting stent implantation in porcine coronary artery: an optical coherence tomography analysis

 Hoyoun Won  ;  Jung-Sun Kim  ;  Dong-Ho Shin  ;  Byeong-Keuk Kim  ;  Young-Guk Ko  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Myeong-Ki Hong 
 BIOMED RESEARCH INTERNATIONAL, Vol.2014 : 851676, 2014 
Journal Title
Issue Date
Animals ; Blood Vessel Prosthesis* ; Coronary Angiography ; Coronary Vessels/drug effects* ; Drug-Eluting Stents* ; Everolimus ; Hyperplasia ; Neointima/drug therapy* ; Neointima/pathology* ; Sirolimus/analogs & derivatives* ; Sirolimus/pharmacology ; Sirolimus/therapeutic use ; Sus scrofa ; Tomography, Optical Coherence/methods*
PURPOSES: The serial changes in neointimal tissues were compared between everolimus-eluting stent (EES) and bare-metal stent (BMS) in the porcine coronary artery using optical coherence tomography (OCT). METHODS: Serial (1, 3, and 6 month follow-up after stent implantation) OCT examinations were performed in 15 swine with 15 BMS- and 15 EES-treated lesions in porcine coronary arteries. RESULTS: In BMS-implanted lesions, neointimal volume decreased from 7.3 mm(3) to 6.9 mm(3) and 6.4 mm(3) at 1, 3, and 6 months follow-up without statistical significance (P = 0.369). At the time points of 1, 3, and 6 months, neointimal tissue appearance was mainly a homogeneous pattern (80.0%, 93.3%, and 100%, resp.), while the other pattern was layered. In contrast, in EES-implanted lesions, neointimal volume significantly increased from 4.8 mm(3) to 9.8 mm(3) between 1 and 3 months but significantly decreased to 8.6 mm(3) between 3 and 6 months (P < 0.001). Between 1 and 3 months, the layered pattern of neointimal tissue increased from 26.7% to 66.7% but decreased to 20.0% between 3 and 6 months. CONCLUSIONS: EES had a biphasic pattern of neointimal amounts that correlated with changes in neointimal morphology.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Byeong Keuk(김병극) ORCID logo https://orcid.org/0000-0003-2493-066X
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shin, Dong Ho(신동호) ORCID logo https://orcid.org/0000-0002-7874-5542
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
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